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52,188 results
  • Crusted scabies in a Pediatric Renal transplant recipient on immunosuppressants. [Journal Article]
    Transpl Infect Dis 2019; :e13193Ede C, Gunduz O, Modi D
  • CONCLUSIONS: This case is the first documented report of CS in a paediatric renal transplant patient. Our management highlights that classic formularies of magistral drugs are still effective treatment options and can be used especially when standard therapies cannot be tolerated or when optimum treatments are not available.
  • Real-world Outcomes of Sequential Androgen-receptor Targeting Therapies with or Without Interposed Life-prolonging Drugs in Metastatic Castration-resistant Prostate Cancer: Results from the Dutch Castration-resistant Prostate Cancer Registry. [Journal Article]
    Eur Urol Oncol 2019Kuppen MCP, Westgeest HM, … Gerritsen WR
  • CONCLUSIONS: A total of 273 patients were included with a median follow-up of 8.4 mo from ART2. Patients with ART1>ART2 were older and had favourable prognostic characteristics at ART2 baseline compared with patients with ART1>LPD>ART2. No differences between ART1>ART2 and ART1>LPD>ART2 were found in PSA response and treatment duration. Multivariate analysis suggested that PSA response of ART2 was less likely in patients with visceral metastases (odds ratio [OR] 0.143, p=0.04) and more likely in patients with a relatively longer duration of androgen-deprivation treatment (OR 1.028, p=0.01) and with ABI + P before ENZ (OR 3.192, p=0.02). A major limitation of this study was missing data, a common problem in retrospective observational research.The effect of ART2 seems to be low, with a low PSA response rate and a short treatment duration irrespective of interposed chemotherapy or radium-223, especially in patients with short time on castration, visceral disease, and ENZ before ABI+P.
  • Disulfiram-like Reaction With Metronidazole: An Unsuspected Culprit. [Case Reports]
    J Pediatr Pharmacol Ther 2019 Sep-Oct; 24(5):445-449Alonzo MM, Lewis TV, Miller JL
  • The association of disulfiram-like reaction with concomitant use of metronidazole and alcohol has been reported in the literature; however, alcohol containing oral liquids may not always be identified as a culprit. A case of a 14-year-old patient who experienced a possible disulfiram-like interaction while receiving metronidazole and Prednisone Intensol solution is reported. Metronidazole oral su…
  • [Diffuse large B-cell lymphoma: standard treatment and research questions]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1193-1198Ohmachi K
  • In 2018 the practical guidelines for hematological malignancies, edited by Japanese Society of Hematology, underwent major revision for the first time in five years. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard treatment for diffuse large B-cell lymphoma (DLBCL) in line with the prior 2013 guidelines. R-CHOP has been considered as the standar…
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