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7,390 results
  • Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents. [Journal Article]
    Molecules 2019; 24(20)Cortés-Percino A, Vega-Báez JL, … Montiel-Smith S
  • A small and focused library of steroidal non-fused and fused pyrimidines was prepared from pregnenolone acetate and diosgenin, respectively. The key step was the cycloaddition reaction of nitrogen-containing 1,3-binucleophiles with the steroidal α,β-unsaturated ketone. Urea, thiourea and guanidine reacted in a similar manner and afforded the steroidal pyrimidines in good yields. The antiprolifera…
  • Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone. [Journal Article]
    Nat Neurosci 2019Frau R, Miczán V, … Melis M
  • The increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, among others, pregnancy-related ailments such as morning sickness. Emerging clinical evidence, however, indicates that prenatal cannabis exposure (PCE) predisposes offspring to various neuropsychiatric disorders linked to aberrant dopaminergic function. Yet, our knowledge of how ca…
  • Pharmacological Activities of Dehydroepiandrosterone: A Review. [Review]
    Steroids 2019; :108507Sahu P, Gidwani B, Dhongade HJ
  • Dehydroepiandrosterone (DHEA) is a steroidal hormone secreted by Zonareticularis of the adrenal cortex with a characteristic age related pattern of secretion. These hormones are inactive precursors that are transformed into active sex steroids in peripheral target tissues. These hormones are used for the energy, vitality and the natural support of most bodily functions that involve the endocrine …
  • L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors. [Journal Article]
    PLoS One 2019; 14(10):e0223272Moffett SX, Klein EA, … Martin JV
  • The nicotinic acetylcholine receptor (nAChR) is an excitatory pentameric ligand-gated ion channel (pLGIC), homologous to the inhibitory γ-aminobutyric acid (GABA) type A receptor targeted by pharmaceuticals and endogenous sedatives. Activation of the GABAA receptor by the neurosteroid allopregnanolone can be inhibited competitively by thyroid hormone (L-3,3',5-triiodothyronine, or T3), but modula…
  • The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression. [Journal Article]
    Mol Pharmacol 2019; 96(5):655-663Touloupi K, Küblbeck J, … Pappas P
  • Aldehyde hydrogenases (ALDHs) belong to a large gene family involved in oxidation of both endogenous and exogenous compounds in mammalian tissues. Among ALDHs, the rat ALDH1A7 gene displays a curious strain dependence in phenobarbital (PB)-induced hepatic expression: the responsive RR strains exhibit induction of both ALDH1A7 and CYP2B mRNAs and activities, whereas the nonresponsive rr strains sh…
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