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6,574 results
  • Erythrocytes as Carriers of Therapeutic Enzymes. [Review]
    Pharmaceutics. 2020 May 08; 12(5)Bax BE
  • Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to induce an advantageous physiological change. However, the metabolic and clinical efficacies of parenterally or intramuscularly administered therape…
  • Enhanced dual function of osteoclast precursors following calvarial Porphyromonas gingivalis infection. [Journal Article]
    J Periodontal Res. 2020 Jun; 55(3):410-425.Cai X, Li Z, … Zhang P
  • CONCLUSIONS: In this study, we demonstrate an enhanced dual function of osteoclast precursors following calvarial Pg infection. Based on our findings, we propose the following model: Pg infection increases a pool of precursor cells that can be shunted toward osteoclast formation at the infection/inflammation sites, while at the same time dampening host immune responses, which is beneficial for the persistence of infection and maintenance of the characteristic chronic nature of periodontitis. Understanding the nature, function, and regulation of osteoclast precursors will be helpful for identifying therapeutic interventions to aid in the control and prevention of inflammatory bone loss diseases including periodontitis.
  • [All-trans retinoic acid promotes differentiation of human leukemia cells by degrading NLS-RARα]. [Journal Article]
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2019 Dec; 35(12):1082-1087.Li J, Liu B, … Zhong L
  • Objective To investigate the effect of all-trans retinoic acid (ATRA) on cell differentiation in nuclear localization signal-retinoic acid receptor-α (NLS-RARα)-overexpressing leukemia cells. Methods Lentivirus was used to infect NB4 and U937 cells to overexpress NLS-RARα. Fluorescent microscope, real-time PCR and Western blot analysis were performed to measure the mRNA and protein expression of …
  • Glucocorticoids uncover a critical role for ASH2L on BCL-X expression regulation in leukemia cells. [Journal Article]
    Biochim Biophys Acta Gene Regul Mech. 2020 01; 1863(1):194475.Rocha-Viegas L, Silbermins M, … Pecci A
  • Targeting the apoptosis machinery is a promising therapeutic approach in myeloid malignancies. BCL2L1 is a well-known glucocorticoid-responsive gene and a key apoptosis regulator that, when over-expressed, can contribute to tumor development, progression and therapeutic resistance. Moreover, synthetic glucocorticoids, like dexamethasone, are frequently used in the treatment of hematopoietic disea…
  • Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer. [Journal Article]
    Int J Mol Sci. 2019 Nov 12; 20(22)Carafa V, Poziello A, … Altucci L
  • Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylases, are promising targets for anticancer treatment. Recently, we characterized a novel pan-sirtuin (SIRT) inhibitor, MC2494, displaying antiproliferative effects and able to induce death pathways in several human cancer cell lines and decrease tumor growth in vivo. Based on the chemical scaffold of MC2494, a…
  • Bisphenol A triggers the malignancy of acute myeloid leukemia cells via regulation of IL-4 and IL-6. [Journal Article]
    J Biochem Mol Toxicol. 2020 Jan; 34(1):e22412.Zhang S, Li J, … Wu X
  • Acute myeloid leukemia (AML) is a cancer of hematopoietic stem cells with a rapid progression. The progression of AML can be regulated by estrogenic signals. Our present data showed that an industrial endocrine-disrupting chemical, bisphenol A (BPA), can promote the proliferation of AML cells and decrease their sensitivity to daunorubicin and cytarabine treatment. Among the tested cytokines, BPA …
  • Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [Journal Article]
    Retrovirology. 2019 11 11; 16(1):32.Telwatte S, Morón-López S, … Yukl SA
  • CONCLUSIONS: HIV-infected cell lines differ from each other and from cells from ART-treated individuals in the mechanisms governing latent HIV infection. These differences in viral and cellular gene expression must be considered when gauging the suitability of a given cell line for future research on HIV. At the same time, some features were shared across cell lines, such as low expression of antiviral defense genes and a relationship between productive infection and genes involved in survival. These features may contribute to HIV latency or persistence in vivo, and deserve further study using novel single cell assays such as those described in this manuscript.
  • Direct qPCR is a sensitive approach to detect Mycoplasma contamination in U937 cell cultures. [Journal Article]
    BMC Res Notes. 2019 Nov 01; 12(1):720.Baaity Z, Breunig S, … Somogyvári F
  • We aim to directly detect Mycoplasma DNA in a U937 suspension cell culture without using DNA purification. In order to make Mycoplasma contamination monitoring easier, we optimized a commercially available quantitative PCR (qPCR)-based detection kit. We compared the sensitivity of direct qPCR against qPCR with a purified DNA template.
  • Defective apoptosis of U937 cells induced by benzyl isothiocyanate (BITC). [Journal Article]
    Acta Biochim Pol. 2019 Oct 24; 66(4):401-407.Stasiłojć G, Nagel A, … Bigda JJ
  • Isothiocyanates precursors (ITCs), including benzyl isothiocyanate (BITC), are considered as cancer chemopreventive agents. ITC derivatives were tested in clinical trials (NCT00005883, NCT01265953, NCT01790204) and preclinical studies aimed to inhibit tumor growth and modulation of their microenvironment. Although efficacy of ITCs was demonstrated with several leukemic cell lines, the final steps…
  • PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae. [Journal Article]
    mSphere. 2019 10 02; 4(5)Ozer EA, Prister LL, … Seifert HS
  • Gene diversification is a common mechanism pathogens use to alter surface structures to aid in immune avoidance. Neisseria gonorrhoeae uses a gene conversion-based diversification system to alter the primary sequence of the gene encoding the major subunit of the pilus, pilE Antigenic variation occurs when one of the nonexpressed 19 silent copies donates part of its DNA sequence to pilE We have de…
  • Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation. [Journal Article]
    Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21113-21119.Wang X, Piersma SJ, … Fremont DH
  • Costimulation is required for optimal T cell activation, yet it is unclear whether poxviruses dedicatedly subvert costimulation during infection. Here, we report that the secreted M2 protein encoded by cowpox virus (CPXV) specifically interacts with human and murine B7.1 (CD80) and B7.2 (CD86). We also show that M2 competes with CD28 and CTLA4 for binding to cell surface B7 ligands, with stronger…
  • 1,25-Dihydroxyvitamin D3 induces human myeloid cell differentiation via the mTOR signaling pathway. [Journal Article]
    Biochem Biophys Res Commun. 2019 11 19; 519(4):909-915.Kim Y, Kim HS, … Ji JD
  • 1,25-Dihydroxyvitamin D3 or 1,25(OH)2D3 is known to play an important role in the differentiation of human myeloid cells. However, the molecular mechanism underlying the 1,25(OH)2D3-mediated differentiation of human myeloid cells is incompletely understood. Here, we report that 1,25(OH)2D3 induces differentiation of human myeloid cell lines such as U937 and THP-1 cells via the mammalian target of…
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