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6,405 results
  • [Role of Pim1 Gene Overexpression in Pathogenesis of Acute Myeloid Leukemia]. [Journal Article]
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019; 27(3):664-672Li Q, Sun RX, … Wu Y
  • CONCLUSIONS: Pim1 plays an important role in the pathogenesis of AML, which not only promotes AML cell proliferation and inhibition of apoptosis, but also enhances the chemotactic ability of leukemia cells, which closely relates with Pim1 phosphorylation of CXCR4 and the increase of intracellular calcium ion influx signals.
  • SERPINB1-mediated checkpoint of inflammatory caspase activation. [Journal Article]
    Nat Immunol 2019; 20(3):276-287Choi YJ, Kim S, … Jung JU
  • Inflammatory caspases (caspase-1, caspase-4, caspase-5 and caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing pro-inflammatory cytokines and triggering pyroptosis. However, precise checkpoints are required to prevent their unsolicited activation. Here we report that serpin family B member 1 (SERPINB1) limited the activity of those caspases by suppressi…
  • Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation. [Journal Article]
    Eur J Pharmacol 2019; 847:42-52Díaz Nebreda A, Zappia CD, … Shayo C
  • Histamine [2-(4-Imidazolyl)-ethylamine] modulates different biological processes, through histamine H1 and H2 receptors, and their respective blockers are widely used in treating allergic and gastric acid-related disorders. Histamine H1 and H2 receptor crossdesensitization and cointernalization induced by its agonists have been previously described. In this study, we show how this crosstalk deter…
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