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116 results
  • Malaria: What's New in the Management of Malaria? [Review]
    Infect Dis Clin North Am 2019; 33(1):39-60Plewes K, Leopold SJ, … Dondorp AM
  • The global burden of malaria remains high, with 216 million cases causing 445,000 deaths in 2016 despite first-line treatment with artemisinin-based combination therapy. Decreasing transmission in Africa shifts the risk for severe malaria to older age groups as premunition wanes. Prompt diagnosis and treatment with intravenous artesunate in addition to appropriate supportive management are critic…
  • Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma? [Review]
    Trends Parasitol 2017; 33(2):93-101Rougier S, Montoya JG, Peyron F
  • It is believed that infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of parasitic cysts which induce immunoprotection against reinfection. A review of the scientific literature since the 1950s did not yield any definitive data regarding the duration of cysts in the host or the presence of lifelong protective immunity, which led us to question this dogm…
  • Effect of HSV-IL12 Loaded Tumor Cell-Based Vaccination in a Mouse Model of High-Grade Neuroblastoma. [Journal Article]
    J Immunol Res 2016; 2016:2568125Bauer DF, Pereboeva L, … Lamb LS
  • We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncolytic IL-12-expressing HSV-1 virus, M002. This vaccine was tested against the syngeneic neuroblastoma mouse model Neuro 2a injected into the right caudate nucleus of the immunocompetent A/J mice. Mice were vaccinated via intramuscular injection of multimodal vaccine or uninfected irradiated tumor ce…
  • Explaining premunition with Kin selection using Haemonchus contortus. [Journal Article]
    Parasitology 2016; 143(9):1187-92Ketzis JK, Fogarty EA, … Bowman DD
  • Premunition is the state in a disease where an existing infection protects the host from reinfection with the same species. The cause of premunition is not clearly understood. In this study, we hypothesized that kin-selection might be a contributing factor in premunition. To test this theory, sheep were infected either once with a linguiform or smooth vulval morphotype of Haemonchos contortus, tw…
  • Consequences of HIV infection on malaria and therapeutic implications: a systematic review. [Review]
    Lancet Infect Dis 2011; 11(7):541-56Flateau C, Le Loup G, Pialoux G
  • Despite recent changes in the epidemiology of HIV infection and malaria and major improvements in their control, these diseases remain two of the most important infectious diseases and global health priorities. As they have overlapping distribution in tropical areas, particularly sub-Saharan Africa, any of their clinical, diagnostic, and therapeutic interactions might have important effects on pa…
  • Natural regulatory T cells in malaria: host or parasite allies? [Review]
    PLoS Pathog 2010; 6(4):e1000771Hansen DS, Schofield L
  • Plasmodium falciparum malaria causes 500 million clinical cases with approximately one million deaths each year. After many years of exposure, individuals living in endemic areas develop a form of clinical immunity to disease known as premunition, which is characterised by low parasite burdens rather than sterilising immunity. The reason why malaria parasites persist under a state of premunition …
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