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195,743 results
  • Exogenous Hydrogen Sulfide Alleviates-Induced Intracellular Inflammation in HepG2 Cells. [Journal Article]
    Exp Clin Endocrinol Diabetes 2019Wang YD, Li JY, … Xiao XH
  • Fatty acids induced hepatic inflammation plays an important role in nonalcoholic fatty liver disease (NAFLD) pathogenesis. Hydrogen sulfide (H2S), an endogenous gasotransmitter, has been established to possess potent anti-inflammation in various human organs. However, the anti-inflammation property of H2S in the fatty liver is still needed to further elucidate. Hence, this study aimed to investig…
  • The gut-liver axis in liver disease: pathophysiological basis for therapy. [Review]
    J Hepatol 2019Albillos A, Gottardi A, Rescigno M
  • The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota, and the liver, resulting from the integration of signals generated by dietary, genetic and environmental factors. This reciprocal interaction is established through the vascular route of the portal vein that carries gut-derived products directly to the liver, and the liver feed-back route of bile and a…
  • Cys-LTs' Pro-phlogistic Lung Actions Are Regulated by Cys-Maresins. [Journal Article]
    J Allergy Clin Immunol 2019Levy BD, Abdulnour RE, … Serhan CN
  • CONCLUSIONS: These results identified lung MCTRs that when added exogenously blocked human LTD4-induced airway contraction and promoted the resolution of murine allergic airway responses. Together, these findings uncover pro-resolving mechanisms for lung responses that may be disrupted in disease.
  • Functional immune monitoring in severely injured patients - a pilot study. [Journal Article]
    Scand J Immunol 2019; :e12837Halbgebauer R, Kellermann S, … Perl M
  • After severe trauma, the resulting excessive inflammatory response is countered by compensatory anti-inflammatory mechanisms. The systemic inflammatory response to trauma enhanced by inappropriately timed surgical second hits may be detrimental for the patient. On the other hand, overwhelming anti-inflammatory mechanisms may put patients at increased risk from secondary local and systemic infecti…
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