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1,510,012 results
  • 14-3-3 gamma, a novel regulator of the large-conductance Ca2+-activated K+ channels. [Journal Article]
    Am J Physiol Renal Physiol. 2020 May 28 [Online ahead of print]Chen S, Feng X, … Cai H
  • 14-3-3 gamma (γ) is a small protein regulating the target proteins through binding to the phosphorylated serine/threonine residues. Sequence analysis of large-conductance Ca2+-activated K+ (BK) channel revealed a putative 14-3-3 binding site in the C-terminal region. Our previous data showed that 14-3-3γ is widely expressed in the mouse kidney. We, therefore, hypothesized that 14-3-3γ has a novel…
  • Utility of repeated therapeutic endoscopies for pediatric esophageal anastomotic strictures. [Journal Article]
    Dis Esophagus. 2020 May 28 [Online ahead of print]Yasuda JL, Taslitsky GN, … Manfredi MA
  • Anastomotic stricture is a common complication of esophageal atresia (EA) repair. Such strictures are managed with dilation or other therapeutic endoscopic techniques such as steroid injections, stenting, or endoscopic incisional therapy (EIT). In situations where endoscopic therapy is unsuccessful, patients with refractory strictures may require surgical stricture resection; however, the point a…
  • Carbonation dysgeusia associated with topiramate. [Journal Article]
    Am J Health Syst Pharm. 2020 May 28 [Online ahead of print]Charbonneau M, Doyle-Campbell C, … Capoccia K
  • CONCLUSIONS: A 39-year-old Caucasian woman with longstanding epilepsy was initiated on topiramate therapy after experiencing a generalized seizure (she reported not taking any antiepileptic medication for years). Topiramate was started at a dosage of 25 mg by mouth twice daily and after 3 weeks titrated to a dosage of 100 mg by mouth twice daily for maintenance therapy. After initiation of topiramate therapy, the patient began to experience an immediate change in her carbonation perception when drinking carbonated beverages; all carbonated beverages, including seltzer and beer, tasted "flat." The patient remained on topiramate for the subsequent 12 months without her carbonation perception returning to normal but noted that drinking carbonated beverages through straws slightly mitigated the adverse effect. Case assessment using the adverse drug reaction probability scale of Naranjo et al indicated that topiramate was the probable cause of the patient's carbonation taste perversion.A 39-year-old Caucasian woman developed chronic carbonation dysgeusia after initiation of topiramate following a generalized seizure.
  • A Rare Access Site Complication after Transcatheter Aortic Valve Implantation. [Case Reports]
    J Tehran Heart Cent. 2019 Oct; 14(4):187-190.Gocer H, Abusharekh M, … Tengiz I
  • In the majority of patients undergoing transcatheter aortic valve implantation, the transfemoral access is the suggested approach due to its less invasive nature and feasibility in patients with suitable vascular anatomy. The complications of the transfemoral access site are generally vascular; however, we herein present a rare case of colon perforation following the transfemoral procedure owing …
  • Cultural evolution of conformity and anticonformity. [Journal Article]
    Proc Natl Acad Sci U S A. 2020 May 27 [Online ahead of print]Denton KK, Ram Y, … Feldman MW
  • Conformist bias occurs when the probability of adopting a more common cultural variant in a population exceeds its frequency, and anticonformist bias occurs when the reverse is true. Conformist and anticonformist bias have been widely documented in humans, and conformist bias has also been observed in many nonhuman animals. Boyd and Richerson used models of conformist and anticonformist bias to e…
  • Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis. [Journal Article]
    Sci Transl Med. 2020 May 27; 12(545)Knevel R, le Cessie S, … Raychaudhuri S
  • It is challenging to quickly diagnose slowly progressing diseases. To prioritize multiple related diagnoses, we developed G-PROB (Genetic Probability tool) to calculate the probability of different diseases for a patient using genetic risk scores. We tested G-PROB for inflammatory arthritis-causing diseases (rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathy, psoriatic arthri…
  • Evolutionary Rescue and Drug Resistance on Multicopy Plasmids. [Journal Article]
    Genetics. 2020 May 27 [Online ahead of print]Santer M, Uecker H
  • Bacteria often carry "extra DNA" in form of plasmids in addition to their chromosome. Many plasmids have a copy number greater than one such that the genes encoded on these plasmids are present in multiple copies per cell. This has evolutionary consequences by increasing the mutational target size, by prompting the (transitory) co-occurrence of mutant and wild-type alleles within the same cell, a…
  • Maladaptive social norms, cultural progress, and the free-energy principle. [Journal Article]
    Behav Brain Sci. 2020 May 28; 43:e100.Colombo M
  • Veissière and collaborators ground their account of culture and social norms in the free-energy principle, which postulates that the utility (or adaptive value) of an outcome is equivalent to its probability. This equivalence would mean that their account entails that complying with social norms has always adaptive value. But, this is false, because many social norms are obviously maladaptive.
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