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4,437 results
  • StatPearls: Procainamide [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Pritchard Brian B The Brooklyn Hospital Center Thompson Holly H The Brooklyn Hospital Center BOOK
  • Procainamide is a medication used in the management and treatment of ventricular arrhythmias, supraventricular arrhythmias, atrial flutter, atrial fibrillation, AV nodal re-entrant tachycardia, and Wolf-Parkinson-White syndrome. It is a Class 1A antiarrhythmic agent.  This activity reviews the literature, indications, action, and contraindications for procainamide as a valuable agent in the treat…
  • StatPearls: Disopyramide [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Sundjaja Joshua H. JH Atma Jaya Catholic University Makaryus Amgad N. AN Zucker School Medicine/Hofstra/Northwell BOOK
  • In 1962, there was a need for new antiarrhythmic drugs other than quinidine and procainamide, the main available antiarrhythmic agents available at that time. From more than 500 compounds synthesized for the research program of new antiarrhythmic agents, disopyramide is the selected agent. The chemical structures of disopyramide have a resemblance to the synthetic muscarinic antagonist, lachesine…
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Antiarrhythmic Agents [BOOK]
    . National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The antiarrhythmics are a heterogeneous group of medications that act to decrease cardiac automaticity and slow conduction, and are used for either or both ventricular and atrial arrhythmias. The most common use of antiarrhythmics is in the treatment of atrial fibrillation or flutter, or prevention of their recurrence in patients after electrical or medical cardioversion. Use of antiarrhythmics f…
  • Isoniazid-Induced Systemic Lupus Erythematosus: A Case Report. [Journal Article]
    Drug Saf Case Rep. 2019 Sep 20; 6(1):7.Vaghela JH, Solanki Y, … Purohit B
  • Systemic lupus erythematosus (SLE) can be induced by various medications, such as hydralazine, procainamide, isoniazid, methyldopa, chlorpromazine, quinidine, and minocycline. A patient was admitted complaining of fever with chills and rigor. After being diagnosed with tuberculous meningitis, the patient was given antituberculosis treatment. As the patient did not improve, detailed investigations…
  • N-acetyltransferase: the practical consequences of polymorphic activity in man. [Review]
    Xenobiotica. 2020 Jan; 50(1):77-91.Mitchell SC
  • Over the years, numerous studies have supported the premise that individuals possessing the "slow acetylator" phenotype are more at risk from developing drug side-effects. Most prominent amongst these reports are those concerned with hepatotoxicity and peripheral neuropathy following treatment with isoniazid, lupus-like symptoms during procainamide therapy and experiencing hypersensitivity reacti…
  • Right coronary anomaly in a patient with myocarditis and cardiac arrest: a case report. [Case Reports]
    Eur Heart J Case Rep. 2018 Jun; 2(2):yty044.Oberli LS, Haegeli LM, Heidecker B
  • Management of coronary anomalies continues to be a controversial topic in medicine, for which only in specific clinical scenarios recommendations for management are clearly defined. We are presenting a previously healthy 18-year-old patient who survived sudden cardiac death (SCD). Multiple potential aetiologies were evaluated, including malignant coronary anomaly, acute myocarditis, potential Bru…
  • Mechanistic Insights of Chemicals and Drugs as Risk Factors for Systemic Lupus Erythematosus. [Journal Article]
    Curr Med Chem. 2019 Apr 04 [Online ahead of print]Pan Q, Guo Y, … Liu HF
  • Systemic lupus erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from clinical application, further investigation of environmental risk factors could re…
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