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1,370 results
  • Prochlorperazine for treatment of acute migraines in adults. [Journal Article]
    Acad Emerg Med 2019Long B, Koyfman A, Gottlieb M
  • Migraine headache results in over 1 million emergency department visits per year in the United States.1-3 Several treatments have been offered to treat the headache.4-6 Prochlorperazine has been tested in randomized trials and, despite adverse effects such as dystonic reactions several societies recommend its use.4,6.
  • Transdermal Delivery of Antipsychotics: Rationale and Current Status. [Journal Article]
    CNS Drugs 2019; 33(9):849-865Abruzzo A, Cerchiara T, … Bigucci F
  • The aim of this article is to provide the rationale for the development of transdermal formulations of antipsychotics by highlighting their main advantages, starting with an overview of the antipsychotic formulations that are currently available on the market. Progress regarding transdermal antipsychotic formulations was investigated by performing a search of papers, patents and clinical trials p…
  • Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex. [Journal Article]
    J Pharmacol Sci 2019; 140(2):197-200Obara K, Horiguchi S, … Tanaka Y
  • Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat dementia. We investigated the inhibitory effects of 26 antipsychotics on [N-Methyl-3H]scopolamine specific binding in mouse cerebral cortex. At 1…
  • Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. [Journal Article]
    Naunyn Schmiedebergs Arch Pharmacol 2019; 392(10):1257-1264Otręba M, Pajor M, Warncke JD
  • Cutaneous melanoma is least common (only about 1% of skin cancers) but is the deadliest malignant tumor. Moreover, amelanotic types of melanoma are very difficult for clinical diagnosis. The standard therapy can cause a lot of side effects, e.g., nausea, vomiting, and headaches, which means that novel and effective strategies are required. Interestingly, phenothiazine derivatives possess sedative…
  • The discovery and development of inhaled therapeutics for migraine. [Journal Article]
    Expert Opin Drug Discov 2019; 14(6):591-599Vandenbussche N, Goadsby PJ
  • Migraine is a disabling primary headache disorder that requires effective treatments. Inhalation is currently being explored for the delivery of drugs for migraine. Pulmonary-route delivery of drugs shows potential advantages for its use as a treatment, particularly compared the oral route. Areas covered: The authors highlight the current state of the literature and review multiple therapies for …
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