- Can Advanced Endoscopic Imaging Help Us Avoid Surgery for Endoscopically Resectable Colorectal Neoplasms? A Proof-of-Concept Study. [Journal Article]Dig Dis Sci 2019DD
- CONCLUSIONS: Therapeutic decision-making according to SCI or AEI can reduce surgery for endoscopically resectable colorectal neoplasms.
- Cost-effectiveness analysis of laparoscopic and open surgery in routine Swedish care for colorectal cancer. [Journal Article]Surg Endosc 2019SE
- CONCLUSIONS: In a national cohort, laparoscopic colorectal cancer surgery was associated with both superior outcomes for clinical effectiveness and cost versus open surgery.
- Redo surgery with longitudinal resection for dilated bowel in Hirschsprung disease: an illustrative case series. [Journal Article]Int J Colorectal Dis 2019IJ
- CONCLUSIONS: Longitudinal resection is a surgical redo-procedure offering large benefits for patients with Hirschsprung disease with distended bowel after primary surgery.
- Karyopherin β1 deletion suppresses tumor growth and metastasis in colorectal cancer (CRC) by reducing MET expression. [Journal Article]Biomed Pharmacother 2019; 120:109127BP
- Colorectal cancer (CRC) has become the third most common type of cancer worldwide, and CRC liver metastasis (CRLM) is associated with poor survival rates. However, the molecular mechanisms driving this phenomenon remain unclear. Karyopherin β1 (KPNB1) is an adaptor protein that transports several proteins to the nuclear, and has been reported to play essential role in regulating many cancer-assoc…
Colorectal cancer (CRC) has become the third most common type of cancer worldwide, and CRC liver metastasis (CRLM) is associated with poor survival rates. However, the molecular mechanisms driving this phenomenon remain unclear. Karyopherin β1 (KPNB1) is an adaptor protein that transports several proteins to the nuclear, and has been reported to play essential role in regulating many cancer-associated pathologies. Nevertheless, its role in CRC is unknown. The study was aimed to explore the role of KPNB1 as a pro-metastatic factor and to reveal the underlying mechanism. Here, the results indicated that KPNB1 expression was markedly increased in CRC samples. KPNB1 expression was gradually up-regulated with CRC development and was tightly correlated with poor prognosis in CRC patients. In vitro results demonstrated that KPNB1 decreasing markedly reduced CRC cell proliferation, migration and invasion, which was positively associated with the expression of MET proto-oncogene (MET). Further analysis revealed that KPNB1 decrease down-regulated the expression of epithelial-mesenchymal transition (EMT)-associated signals. In vivo experiments also demonstrated that KPNB1 knockdown evidently inhibited the tumor growth and metastasis in a CRC xenograft model. Importantly, we found that KPNB1 could interact with MET to modulate cell proliferation and metastasis in CRC. A subsequent mechanistic study illustrated that MET over-expression markedly eliminated KPNB1 silence-inhibited migration and invasion in CRC cells. In summary, KPNB1 deletion repressed the metastasis of CRC cells through interacting with MET, which could be served as a potential prognostic biomarker in CRC patients.
- Cost-effectiveness of Active Identification and Subsequent Colonoscopy Surveillance of Lynch Syndrome Cases. [Journal Article]Clin Gastroenterol Hepatol 2019CG
- CONCLUSIONS: Immunohistochemical testing for Lynch syndrome in persons younger than 70 years who received a diagnosis of colorectal cancer, and then testing first-degree relatives of those found to have Lynch syndrome, provides a good balance between costs and long-term benefits. Colonoscopy surveillance every 2 years is the optimal surveillance interval for patients with Lynch syndrome.
- Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice. [Journal Article]Life Sci 2019; :116968LS
- CONCLUSIONS: Nrf2 target genes deserve exploration as prognostic and therapeutic targets for CRC.
- Systemic Amyloid Light-chain amyloidosis with colonic involvement complicated by colo-colic intussusception. [Journal Article]ANZ J Surg 2019AJ
- Microscopic inflammation at ileocaecal resection margins in Crohn's disease: prevent recurrence or treat residual disease? [Journal Article]J Crohns Colitis 2019JC
- Stepwise neoadjuvant chemoradiotherapy in the management of mid-low locally advanced rectal cancer. [Journal Article]Eur J Surg Oncol 2019EJ
- CONCLUSIONS: Compared with the CRT group, the SCRT group had a similar treatment response, local control and long-term prognosis, and more importantly, a portion of the patients in the SCRT group were exempted from excessive radiation.
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- Segmental cytomegalovirus colitis mimicking sigmoid tumor in an immunocompetent patient. [Journal Article]Turk J Gastroenterol 2019; 30(10):932-934TJ