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76,986 results
  • Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer. [Journal Article]
    Horm Cancer 2020Fowler AM, Salem K, … Mahajan AM
  • Tumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the progesterone receptor (PGR) gene in this population. The study objective was to determine the frequency and prognostic significance of tumor PGR mutations for pa…
  • The Influence of Health Care Utilization on the Association between Hormonal Contraception Initiation and Subsequent Depression Diagnosis and Antidepressant Use. [Journal Article]
    Contraception 2020Ditch S, Roberts TA, Hansen S
  • CONCLUSIONS: When compared to women utilizing their health insurance, associations between initiating hormonal contraception and depression diagnosis and antidepressant use decreased or disappeared. This suggests that healthcare utilization may have confounded previous reports of an association between hormonal contraception use and depression and antidepressant use.Population-based studies have shown an association between starting hormonal contraception and subsequent depression diagnoses. In this study, adjusting for healthcare utilization eliminated this association for most hormonal contraceptive types. This suggests that providers can safely prescribe these medications without significantly increasing the risk of depression diagnoses or antidepressant use.
  • Progestogen-only pills: which progestogen would be ideal. [Review]
    Horm Mol Biol Clin Investig 2020Egarter C
  • Compared with nonuse, combined hormonal contraceptives containing estrogen and a progestogen are associated with a roughly 2- to 3-fold increased risk of venous and a 2-fold increased risk of arterial thromboembolism, including stroke and acute myocardial infarction. These events are, however, overall rare among women of reproductive age. Historically, progestin-only pills were not thought to be …
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