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Unbound Medicine.
(propoxycaine hydrochloride)
269 results
  • Postoperative Corneal Injuries: Incidence and Risk Factors. [Journal Article]
    Anesth Analg. 2019 Sep; 129(3):737-742.Deljou A, Weingarten TN, … Martin DP
  • CONCLUSIONS: Calculation of incidence by using the administration of a medication (proparacaine eye drops) that is almost exclusively used to diagnose a specific injury (corneal injury) showed higher case ascertainment percentage than incident-reporting methods. Similar strategies could be used to monitor the rates of other adverse events.
  • Serotonin enhances oxybuprocaine- and proxymetacaine-induced cutaneous analgesia in rats. [Journal Article]
    Eur J Pharmacol. 2019 Mar 05; 846:73-78.Chou AK, Chiu CC, … Hung CH
  • The aim of the study was to investigate the analgesic effects of adding serotonin to oxybuprocaine or proxymetacaine preparations. We employed a rat model of the cutaneous trunci muscle reflex (CTMR) to conduct the dose-response curves and duration of drugs (oxybuprocaine, proxymetacaine, or serotonin) as an infiltrative anesthetic. The use of isobolographic methods to analyze the drug-drug inter…
  • Shelf Life and Efficacy of Diagnostic Eye Drops. [Journal Article]
    Optom Vis Sci. 2018 10; 95(10):947-952.Hanssens JM, Quintana-Giraldo C, … Bouchard JF
  • CONCLUSIONS: According to the results of the current study, diagnostic eye drops can be used with a low contamination risk beyond the recommendation date of 28 days up to 7 months, with the same efficacy, in a controlled clinical context.
  • Central Connections of the Lacrimal Functional Unit. [Journal Article]
    Cornea. 2017 Aug; 36(8):898-907.Willshire C, Buckley RJ, Bron AJ
  • CONCLUSIONS: The wetting length was reduced by topical anesthesia, when instilled bilaterally and ipsilaterally. The latter response implies an ipsilateral, reflex sensory drive to lacrimal secretion. In the unanesthetized fellow eye, the reduction compared with its saline control was not quite significant. This implies a relative lack of central, sensory, reflex cross-innervation, although the possibility cannot entirely be ruled out. These results are relevant to the possibility of reflex lacrimal compensation from a normal fellow eye, in cases of unilateral corneal anesthesia.
  • Proparacaine-Induced Mydriasis During Strabismus Surgery. [Journal Article]
    Semin Ophthalmol. 2018; 33(3):367-370.Takkar B, Sharma P, … Ramachandran R
  • CONCLUSIONS: PH has a mydriatic effect of its own. It penetrates through the bare sclera and leads on to skewed dilation of the pupil. Surgeons should consider this effect while judging pupil alignment at the end of the surgery.
  • The psychological impact of eyedrops administration in children. [Journal Article]
    J AAPOS. 2015 Aug; 19(4):338-43.Sujuan JL, Handa S, … Chia A
  • CONCLUSIONS: A small group of children were uncooperative with eyedrops and 26% experienced significant pre-drop anxiety. Factors such as age, sex, a previous negative eyedrop experience, and pre-drop anxiety, associated with uncooperativeness need to be considered when developing strategies to improve the eyedrops experience in children.
  • Cytotoxicity of proparacaine to human corneal endothelial cells in vitro. [Journal Article]
    J Toxicol Sci. 2015 Aug; 40(4):427-36.Wen Q, Fan T, … Sui Y
  • Proparacaine is a widely used topical anesthetic in ophthalmic optometry and surgery, and has been reported to have cytotoxic effects on rabbit corneal endothelial cells after prolonged and repeated usage. Since rabbit is an exceptive mammal whose corneal endothelial cells still maintaining proliferation abilities even in adulthood, whether proparacaine has cytotoxic effects on human corneal endo…
  • Corneal sensitivity following lacrimal gland excision in the rat. [Journal Article]
    Invest Ophthalmol Vis Sci. 2015 May; 56(5):3347-54.Meng ID, Barton ST, … Kurose M
  • CONCLUSIONS: These results indicate that aqueous tear deficiency produces hypersensitivity in the rat cornea. In addition, the increase in spontaneous blinks and their reduction by morphine and topical anesthesia indicate the presence of persistent irritation elicited by the activation of corneal nociceptors.
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