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Unbound Medicine.
(propoxyphene hydrochloride propoxyphene napsylate)
61 results
  • Propoxyphene and pain management in the elderly. [Journal Article]
    S D Med. 2009 Nov; 62(11):433-5.Mort JR, Schroeder SD
  • Pain is frequently reported and often undertreated in the elderly population. In light of these concerns, it is important to examine potentially ineffective or problematic pain medications. Propoxyphene is one such agent whose efficacy and safety have been questioned by researchers, clinicians and the U.S. Food and Drug Administration (FDA). Specifically, multiple studies have found propoxyphene …
  • Delayed toxic acetaminophen level after initial four hour nontoxic level. [Case Reports]
    J Toxicol Clin Toxicol. 1994; 32(4):431-4.Tighe TV, Walter FG
  • Antidotal therapy for acetaminophen poisoning is routinely based on a single acetaminophen level obtained four or more hours after ingestion. Some experts recommend additional acetaminophen levels if there are coingestants. This case report describes a 20-year-old woman who ingested acetaminophen 13 g, propoxyphene napsylate 2 g and naproxen sodium 3.75 g. A 4.5 h acetaminophen level was 83.5 mg/…
  • Analgesic oral efficacy of tramadol hydrochloride in postoperative pain. [Randomized Controlled Trial]
    Clin Pharmacol Ther. 1992 Jun; 51(6):740-6.Sunshine A, Olson NZ, … Minn FL
  • Tramadol hydrochloride is a synthetic opiate agonist with a plasma elimination half-life of 5 to 6 hours and peak plasma levels at about 1 1/2 hours. It derives its activity from attachment to the mu-receptor and blockage of norepinephrine reuptake. The purpose of this single-dose, double-blind, placebo-controlled study was to determine the analgesic effectiveness of an oral administration of two…
  • Pharmacologic interventions for the treatment of opioid dependence and withdrawal. [Review]
    DICP. 1990 Jul-Aug; 24(7-8):721-34.Guthrie SK
  • This article discusses current pharmacologic methods in the treatment of heroin dependence and withdrawal. Methadone hydrochloride, the most commonly used opiate agonist, is used for both withdrawal and maintenance therapy. However, it produces dependence and withdrawal results upon abrupt discontinuation. Other opiate agonists including L-alpha acetyl methadyl (LAAM) and propoxyphene napsylate h…
  • Amiprilose hydrochloride for rheumatoid arthritis. [Randomized Controlled Trial]
    Ann Intern Med. 1989 Sep 15; 111(6):455-65.Riskin WG, Gillings DB, Scarlett JA
  • CONCLUSIONS: Amiprilose HCl has significant anti-inflammatory activity and a favorable safety profile when used as the sole antirheumatic therapy in patients with active rheumatoid arthritis. Synthetic carbohydrates may represent an important new class of drugs for the treatment of inflammatory, autoimmune diseases.
  • Effect of pretreatment with acetaminophen-propoxyphene for oral surgery pain. [Randomized Controlled Trial]
    J Oral Maxillofac Surg. 1987 Feb; 45(2):99-103.Liashek P, Desjardins PJ, Triplett RG
  • To determine the effect of pretreatment and multiple doses on postsurgical pain, a study of the relative analgesic efficacy of placebo, acetaminophen 650 mg, and propoxyphene napsylate 100 mg alone and in combination was conducted. Forty-five patients undergoing surgical removal of impacted third molar teeth under local anesthesia were randomly allocated to the four treatment regimens under doubl…
  • Propoxyphene in children with iatrogenic morphine dependence. [Case Reports]
    Am J Dis Child. 1983 Aug; 137(8):745-8.Hasday JD, Weintraub M
  • In four children with iatrogenic morphine sulfate tolerance and dependence, narcotic withdrawal was successfully accomplished using propoxyphene napsylate. The patients showed signs and symptoms typical of narcotic withdrawal, which resolved with morphine administration and increased during attempts to lower the daily morphine dose. Propoxyphene napsylate at total daily doses of 25 to 65 mg/kg, a…
  • Decreased absorption of propoxyphene by activated charcoal. [Journal Article]
    J Toxicol Clin Toxicol. 1982 Apr; 19(2):129-38.Glab WN, Corby DG, … Coldiron VR
  • In 1968 we first suggested that activated charcoal (AC) should be administered in the emergency treatment of propoxyphene overdosage. The dramatic increase in recent years of deaths involving propoxyphene has prompted us to again evaluate the efficacy of AC in preventing absorption of propoxyphene from the GI tract. Male rats (100-125 g) were administered propoxyphene hydrochloride (P-HCl, 350 mg…
  • Postsurgical pain: zomepirac sodium, propoxyphene/-acetaminophen combination, and placebo. [Clinical Trial]
    J Clin Pharmacol. 1981 Oct; 21(10):443-8.Honig S, Murray KA
  • Zomepirac sodium, a new, nonnarcotic analgesic agent, was compared with the combination of propoxyphene/acetaminophen in a placebo-controlled, double-blind, single-dose study in 196 hospitalized postsurgical patients with pain severe enough to require a prescription analgesic. Patients received 100 mg zomepirac sodium, 50 mg zomepirac sodium, 100 mg propoxyphene napsylate with 650 mg acetaminophe…
  • Intravenous self-administration of propoxyphene napsylate: case report and in-vitro studies. [Case Reports]
    Clin Toxicol. 1981 Sep; 18(9):1099-104.Green HM, Decker WJ
  • A man who was prescribed propoxyphene napsylate (PN) for treatment of heroin addiction stated that he received no effect from the drug by the oral route. He then decided to administer the drug to himself intravenously in a manner identical to that used by most heroin addicts (heating the tablet with water in a spoon and drawing the liquid through a needle); this procedure brought him immediate su…
  • Propoxyphene napsylate maintenance treatment for narcotic dependence: a non-methadone model. [Journal Article]
    Drug Alcohol Depend. 1981 Aug; 8(1):79-83.Tennant FS, Rawson RA
  • One hundred and seventy eight heroin addicts entered propoxyphene napsylate (PN) maintenance. Patients attended a general medical clinic twice each week and took home a three- to four-day supply of PN, to be taken in doses of 300 to 400 mg three or four times per day. Over a 21-month period, subjects entered and re-entered PN treatment 266 times (1.5 times per patient) and remained in treatment a…
  • Propoxyphene form maintenance treatment of narcotic addiction. [Controlled Clinical Trial]
    Arch Gen Psychiatry. 1981 Aug; 38(8):898-900.Woody GE, Mintz J, … Marcovici M
  • Two studies compared propoxyphene napsylate (Darvon-N) with methadone hydrochloride as maintenance treatment for narcotic addicts. Most measures indicated that methadone was more effective than propoxyphene as a maintenance drug. Patients receiving propoxyphene reported more withdrawal-related symptoms early in treatment, tended to drop out sooner than patients receiving methadone, and were more …
  • Propoxyphene napsylate compared to methadone for opiate dependence. [Randomized Controlled Trial]
    Psychopharmacology (Berl). 1981; 75(4):335-8.Wang RI, Kochar C, … Roh BL
  • When high single doses of propoxyphene napsylate (PN) were given to patients on a methadone maintenance program, results indicated that, to avoid undesirable side effects, the dose should not exceed 600 mg. However, when PN was given in divided doses (800 mg/day in two equal doses), no significant adverse reactions were noted. In the double-blind comparison of 800 mg PN in two divided doses versu…
  • Evaluation of acetaminophen, propoxyphene, and their combination in office practice. [Controlled Clinical Trial]
    J Clin Pharmacol. 1979 Apr; 19(4):227-30.Messick RT
  • Thirty-two patients with chronic painful disease treated in office practice willingly participated in a double-blind, crossover analgesic study. They were informed about (1) the medications--placebo, 650 mg acetaminophen, 100 mg propoxyphene napsylate, and the combination of the two active drugs; (2) the regimen--four to six single-tablet doses per day for two days, crossover; (3) the reporting s…
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