- Transparent carbon nanotubes promote the outgrowth of enthorino-dentate projections in lesioned organ slice cultures. [Journal Article]
- DNDev Neurobiol 2019 Jul 17
- The increasing engineering of carbon-based nanomaterials as components of neuro-regenerative interfaces is motivated by their dimensional compatibility with subcellular compartments of excitable cell…
The increasing engineering of carbon-based nanomaterials as components of neuro-regenerative interfaces is motivated by their dimensional compatibility with subcellular compartments of excitable cells, such as axons and synapses. In neuroscience applications, carbon nanotubes (CNTs) have been used to improve electronic device performance by exploiting their physical properties. Besides, when manufactured to interface neuronal networks formation in vitro, CNT carpets have shown their unique ability to potentiate synaptic networks formation and function. Due to the low optical transparency of CNTs films, further developments of these materials in neural prosthesis fabrication or in implementing interfacing devices to be paired with in vivo imaging or in vitro optogenetic approaches are currently limited. In the present work, we exploit a new method to fabricate CNTs by growing them on a fused silica surface, which results in a transparent CNT-based substrate (tCNTs). We show that tCNTs favour dissociated primary neurons network formation and function, an effect comparable to the one observed for their dark counterparts. We further adopt tCNTs to support the growth of intact or lesioned Entorhinal-Hippocampal Complex organotypic cultures (EHCs). Through immunocytochemistry and electrophysiological field potential recordings, we show here that tCNTs platforms are suitable substrates for the growth of EHCs and we unmask their ability to significantly increase the signal synchronization and fibre sprouting between the cortex and the hippocampus with respect to Controls. tCNTs transparency and ability to enhance recovery of lesioned brain cultures, make them optimal candidates to implement implantable devices in regenerative medicine and tissue engineering. This article is protected by copyright. All rights reserved.
- A Computational Study on Deformed Bioprosthetic Valve Geometries: Clinically Relevant Valve Performance Metrics. [Journal Article]
- JBJ Biomech Eng 2019 Jul 17
- Transcatheter aortic valves (TAV) are symmetrically designed, but they are often not deployed inside cylindrical conduits with circular cross-sectional areas. Many TAV patients have heavily calcified…
Transcatheter aortic valves (TAV) are symmetrically designed, but they are often not deployed inside cylindrical conduits with circular cross-sectional areas. Many TAV patients have heavily calcified aortic valves, which often result in deformed prosthesis geometries after deployment. We investigated the effects of deformed valve annulus configurations on a surgical bioprosthetic valve as a model for TAV. We studied valve leaflet motions, stresses and strains, and analogue hydrodynamic measures (using geometric methods), via finite element modeling. Two categories of annular deformations were created to approximate clinical observations: 1) non-circular annulus with valve area conserved, and 2) under-expansion (reduced area) compared to circular annulus. We found that under-expansion had more impact on increasing stenosis than non-circularity, and that non-circularity had more impact on increasing regurgitation than under-expansion. We found durability predictors (stress/strain) to be highest in commissure regions of non-circular configurations. This study adds more evidence for considering the clinical impacts of TAV deformation on acute and long-term valve performance in the design and testing phase of device development.
- Autoperception of food conditions of elderly dental prosthetic users. [Journal Article]
- CCodas 2019 Jul 15; 31(3):e20180080
- CONCLUSIONS: The elderly rarely complaint about discomfort or embarrassment on feeding, however, they present an average lower than expected in the GOHAI index, which indicates that, although they do not report it, many deteriorations, that seem to be natural may be happening and may be the cause of worst quality of life.
- Gram-negative enteric rods/Pseudomonas colonization in mucositis and peri-implantitis of implants restored with cemented and screwed reconstructions: A cross-sectional study. [Journal Article]
- CIClin Implant Dent Relat Res 2019 Jul 16
- CONCLUSIONS: The presence of Gram-negative enteric rods/Pseudomonas was associated with cemented restored implants; besides, peri-implantitis was associated with cemented restored implants.
- Generic implant classification enables comparison across implant designs: the Dutch Arthroplasty Register implant library. [Review]
- EOEFORT Open Rev 2019; 4(6):344-350
- In the Dutch Arthroplasty Register (LROI), the product and batch number of prosthetic components and cement are registered for traceability. Registration of the product number provides opportunities …
In the Dutch Arthroplasty Register (LROI), the product and batch number of prosthetic components and cement are registered for traceability. Registration of the product number provides opportunities to extend the information about a specific prosthesis. All product numbers used from the beginning of the registration in 2007 were characterized to develop and maintain an implant library.The Scientific Advisory Board developed a core-set that contains the most important characteristics needed to form an implant library. The final core-set contains the brand name, type, coating and material of the prosthesis. In total, 35 676 product numbers were classified, resulting in a complete implant library of all product numbers used in the LROI.To improve quality of the data and increase convenience of registration, the LROI implemented barcode scanning for data entry into the database. In 2017, 82% of prosthetic components and cement stickers had a GS1 barcode. The remaining product stickers used HIBCC barcodes and custom-made barcodes.With this implant library, implants can be grouped for analyses at group level, e.g. evaluation of the effect of a material of a prosthesis on survival of the implant. Apart from that, the implant library can be used for data quality control within the LROI database.The implant library reduces the registration burden and increases accuracy of the database. Such a system will facilitate new designs (learning from the past) and thus improve implant quality and ultimately patient safety. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180063.
- Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India. [Journal Article]
- OROrthop Rev (Pavia) 2019 May 23; 11(2):8070
- Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate…
Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti-MRSA agents have their own limitations with regards to reduced susceptibility as well as safety and tolerability. Furthermore, biofilms over the prosthesis with invariably multi-drug resistant strains leads to complex treatment processes. This necessitates the need to develop and screen new antibiotics against MRSA that can easily penetrate the deep pockets of infection and take care of the challenges discussed. This review aims to discuss on MRSA infection in bone and joint infection, current antibiotic regimen, its associated limitations, and finally, the need to develop new antibiotic therapy for effective management of patients with BJI.
- Quality of Life Associated Factors in a North African Sample of Lower Limbs Amputees. [Journal Article]
- ARAnn Rehabil Med 2019; 43(3):321-327
- CONCLUSIONS: In our sample of North African lower limbs amputees the age and the functional status were the most important predictors of the quality of life.
- Long-term antimicrobial suppression prevents treatment failure of streptococcal periprosthetic joint infection. [Journal Article]
- JIJ Infect 2019 Jul 13
- CONCLUSIONS: Long-term antimicrobial suppression was associated with significantly better outcome and should be strongly considered in streptococcal PJI.
- Geometric Evaluation of the Effect of Prosthetic Rehabilitation on Facial Asymmetry in Mandibulectomy Patients. [Journal Article]
- IJInt J Prosthodont 2019 May/Jun; 32(3):293-296
- CONCLUSIONS: Wearing a mandibular prosthesis notably improved facial asymmetry.
New Search Next
- First Two Brazilian Cases: Correction of Ascending Aortic Aneurysm and Aortic Valve Stenosis with Sutureless/Rapid Deployment Aortic Prosthesis. [Case Reports]
- BJBraz J Cardiovasc Surg 2019 Jun 01; 34(3):366-367
- Ascending aortic aneurysm is usually associated with aortic valve diseases, especially aortic stenosis. The standard technique involves the substitution of the dilated aortic segment with a Dacron tu…
Ascending aortic aneurysm is usually associated with aortic valve diseases, especially aortic stenosis. The standard technique involves the substitution of the dilated aortic segment with a Dacron tube and replacement of the aortic valve with a regular prosthesis. The correction of ascending aortic aneurysm with aortic valve replacement using the new sutureless and rapid deployment prosthesis was performed by a minimally invasive approach and for the first time in a Brazilian Center.