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75,794 results
  • The potential and controversy of targeting STAT family members in cancer. [Review]
    Semin Cancer Biol 2019Verhoeven Y, Tilborghs S, … van Dam PA
  • The Signal Transducer and Activator of Transcription (STAT) family of proteins consists of transcription factors that play a complex and essential role in the regulation of physiologic cell processes, such as proliferation, differentiation, apoptosis and angiogenesis, and serves to organize the epigenetic landscape of immune cells. To date, seven STAT genes have been identified in the human genom…
  • No evidence of Gremlin1-mediated activation of VEGFR2 signalling in endothelial cells. [Journal Article]
    J Biol Chem 2019Dutton LR, O' Neill CL, … Brazil DP
  • Canonical Gremlin1 (GREM1) signaling involves binding to and sequestering bone morphogenetic proteins (BMPs) in the extracellular matrix, preventing the activation of cognate BMP receptor signaling. Exquisite temporospatial control of the GREM1-BMP interaction is required during development, and perturbation of this balance leads to abnormal limb formation and defective kidney development. In add…
  • Ovarian stimulated cycles reduce protection of follicular fluid against free radicals. [Journal Article]
    Free Radic Biol Med 2019Pérez-Ruiz I, Meijide S, … Ruiz-Sanz JI
  • Controlled ovarian hyperstimulation cycle with exogenous gonadotropins (COH) is associated with clinical complications. The aim of this work was to determine whether COH alters the physiological antioxidant status of follicular fluid in women with no reproductive dysfunction, compared to the natural cycle (NC). In this longitudinal study, forty-one women (oocyte donors) consecutively underwent NC…
  • Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. [Journal Article]
    Science 2019; 366(6462)Brüning F, Noya SB, … Robles MS
  • The circadian clock drives daily changes of physiology, including sleep-wake cycles, through regulation of transcription, protein abundance, and function. Circadian phosphorylation controls cellular processes in peripheral organs, but little is known about its role in brain function and synaptic activity. We applied advanced quantitative phosphoproteomics to mouse forebrain synaptoneurosomes isol…
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