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(proteolytic)
101,801 results
  • Smoking affects gene expression in blood of patients with ischemic stroke. [Journal Article]
    Ann Clin Transl Neurol 2019Cheng X, Ferino E, … Sharp FR
  • CONCLUSIONS: We propose some of the 10 genes that are elevated in both IS-SM and C-SM (GRP15, LRRN3, CLDND1, ICOS, GCNT4, VPS13A, DAP3, SNORA54, HIST1H1D, and SCARNA6) might contribute to increased risk of stroke in current smokers, and some genes expressed by blood leukocytes and platelets after stroke in smokers might contribute to worse stroke outcomes that occur in smokers.
  • Programmable biomolecular switches for rewiring flux in Escherichia coli. [Journal Article]
    Nat Commun 2019; 10(1):3751Gao C, Hou J, … Liu L
  • Synthetic biology aims to develop programmable tools to perform complex functions such as redistributing metabolic flux in industrial microorganisms. However, development of protein-level circuits is limited by availability of designable, orthogonal, and composable tools. Here, with the aid of engineered viral proteases and proteolytic signals, we build two sets of controllable protein units, whi…
  • Nononcogenic restoration of the intestinal barrier by E. coli-delivered human EGF. [Journal Article]
    JCI Insight 2019; 4(16)Yu M, Kim J, … Moon Y
  • Although mucoactive proteins, such as epidermal growth factor (EGF), could improve clinical outcomes of intestinal ulcerative diseases, their gastrointestinal application is limited because of their proteolytic digestion or concerns about tumor promotion. In the present study, ATP-binding cassette (ABC) transporter-linked secretion of human EGF from probiotic Escherichia coli (EGF-EcN) was create…
  • Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction. [Journal Article]
    JCI Insight 2019; 4(16)Sandireddy R, Cibi DM, … Singh MK
  • Left ventricular noncompaction (LVNC) is one of the most common forms of genetic cardiomyopathy characterized by excessive trabeculation and impaired myocardial compaction during fetal development. Patients with LVNC are at higher risk of developing left/right ventricular failure or both. Although the key regulators for cardiac chamber development are well studied, the role of semaphorin (Sema)/p…
  • Functional Characterization of Secreted Aspartyl Proteases in Candida parapsilosis. [Journal Article]
    mSphere 2019; 4(4)Singh DK, Németh T, … Gácser A
  • Candida parapsilosis is an emerging non-albicans Candida species that largely affects low-birth-weight infants and immunocompromised patients. Fungal pathogenesis is promoted by the dynamic expression of diverse virulence factors, with secreted proteolytic enzymes being linked to the establishment and progression of disease. Although secreted aspartyl proteases (Sap) are critical for Candida albi…
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