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(proteolytic)
105,329 results
  • PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema. [Journal Article]
    Am J Respir Cell Mol Biol. 2020 Jul 14 [Online ahead of print]Adini A, Wu H, … Matthews BD
  • Emphysema is a progressive and fatal lung disease with no cure that is characterized by thinning, enlargement and destruction of alveoli leading to impaired gas exchange. Disease progression is due in part to dysregulation of Vascular Endothelial Growth Factor (VEGF) signaling in the lungs and increased lung cell apoptosis. Here we asked whether PR1P, a novel short peptide we designed that increa…
  • Tumor Necrosis Factor-α Trimer Disassembly and Inactivation via Peptide-Small Molecule Synergy. [Journal Article]
    ACS Chem Biol. 2020 Jul 14 [Online ahead of print]Checco JW, Eddinger GA, … Gellman SH
  • Aberrant signaling by tumor necrosis factor-α (TNFα) is associated with inflammatory diseases that can be treated with engineered proteins that inhibit binding of this cytokine to cell-surface receptors. Despite these clinical successes, there is considerable interest in the development of smaller antagonists of TNFα-receptor interactions. We describe a new 29-residue α/β-peptide, a molecule that…
  • Mechanisms of Antimicrobial and Anti-Endotoxin Activities of a Triazine-Based Amphipathic Polymer. [Journal Article]
    Biotechnol Bioeng. 2020 Jul 14 [Online ahead of print]Kim EY, Kumar SD, … Shin SY
  • TZP4 is a triazine-based amphipathic polymer designed to mimic the amphipathic structure found in antimicrobial peptides. TZP4 showed potent antimicrobial activity comparable to melittin against antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa. TZP4 showed high resistance to proteolytic degradation and low tendency t…
  • The other side of the corona: nanoparticles inhibit the protease taspase1 in a size-dependent manner. [Journal Article]
    Nanoscale. 2020 Jul 14 [Online ahead of print]van den Boom J, Hensel A, … Knauer SK
  • When nanoparticles enter a physiological environment, they rapidly adsorb biomolecules, in particular cellular proteins. This biological coating, the so-called nanoparticle protein corona, undoubtedly affects the biological identity and potential cytotoxicity of the nanomaterial. To elucidate a possible impact on the adsorbed biomolecules, we focused on an important group of players in cellular h…
  • Control of allosteric electrochemical protein switch using magnetic signals. [Journal Article]
    Chem Commun (Camb). 2020 Jul 14 [Online ahead of print]Bollella P, Edwardraja S, … Katz E
  • We report a novel approach for magneto-controlled activation of an artificial electro-enzymatic cascade. The input signal triggers release of a caged ligand peptide, its proteolytic processing and activation of an artificial allosteric enzyme based on PQQ-dependent glucose dehydrogenase. The developed cascade was used to assemble a magneto-controlled biofuel cell.
  • On the cutting edge: protease-based methods for sensing and controlling cell biology. [Review]
    Nat Methods. 2020 Jul 13 [Online ahead of print]Chung HK, Lin MZ
  • Sequence-specific proteases have proven to be versatile building blocks for tools that report or control cellular function. Reporting methods link protease activity to biochemical signals, whereas control methods rely on engineering proteases to respond to exogenous inputs such as light or chemicals. In turn, proteases have inherent control abilities, as their native functions are to release, act…
  • Proapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly. [Journal Article]
    Angew Chem Int Ed Engl. 2020 Jul 13 [Online ahead of print]Gianneschi NC, Sun H, … Stupp S
  • Herein we report photoinitiated polymerization-induced self-assembly (photo-PISA) of spherical micelles consisting of proapoptotic peptide-polymer amphiphiles. The one-pot synthetic approach yielded micellar nanoparticles at high concentrations and at scale (150 mg/mL) with tunable peptide loadings up to 48 wt. %. The size of the micellar nanoparticles was tuned by varying the lengths of hydropho…
  • Cyclotide structures revealed by NMR, with a little help from X-ray crystallography. [Journal Article]
    Chembiochem. 2020 Jul 12 [Online ahead of print]Handley TNG, Harvey PJ, … Craik D
  • This article highlights the predominant role that NMR has had in determining the structures of cyclotides, a fascinating class of macrocyclic peptides found in plants. Cyclotides contain a cystine knot, a compact structural motif that is constrained by three disulfide bonds and able to resist chemical and biological degradation. Their resistance to proteolytic degradation has made cyclotides appe…
  • Recovery of human mesenchymal stem cells grown on novel microcarrier coated with thermoresponsive polymer. [Journal Article]
    J Artif Organs. 2020 Jul 12 [Online ahead of print]Narumi Y, Iwai R, Takagi M
  • The cultivation of cells on microcarriers (MCs) in stirred suspension system is useful method for the large-scale culture of human mesenchymal stem cells (hMSCs) for allogenic transplantation. To harvest hMSCs from MCs without using proteolytic enzyme treatment but by lowering temperature, polystyrene MCs coated with a copolymer called CAT having zwitterionic and thermoresponsive characteristics,…
  • Heptameric Peptide Interferes with Amyloid-β Aggregation by Structural Reorganization of the Toxic Oligomers. [Journal Article]
    ACS Omega. 2020 Jul 07; 5(26):16128-16138.Bhattacharyya R, Bhattacharjee S, … Sengupta J
  • Pathogenesis of Alzheimer's disease (AD), the most common type of dementia, involves misfolding and aggregation of the extracellular amyloid-β (Aβ) protein where the intermediate oligomers, formed during the aggregation progression cascade, are considered the prime toxic species. Here, we identify an active peptide fragment from a medicinal plant-derived (Aristolochia indica) fibrinolytic enzyme …
  • Nutritional management of a kitten with thermal burns and septicaemia. [Case Reports]
    JFMS Open Rep. 2020 Jan-Jun; 6(1):2055116920930486.Birkbeck R, Donaldson R, Chan DL
  • A 3-month-old entire female British Shorthair cat presented for further management of thermal burns after falling into a bath of scalding water. On presentation to the primary care clinician the kitten was obtunded, markedly painful and relatively bradycardic, consistent with a state of shock. The haircoat was wet, with erythematous skin and sloughing from the digital pads and anal mucosa. The pr…
  • Compositional and immunogenic evaluation of fractionated wheat beers using mass spectrometry. [Journal Article]
    Food Chem. 2020 Jul 05; 333:127379.Cao W, Baumert JL, Downs ML
  • The safety and regulatory status of fermented products derived from gluten-containing grains for patients with celiac disease remains controversial. Bottom-up mass spectrometry (MS) has complemented immunoassays for the compositional and immunogenic analyses of wheat beers. However, uncharacterized proteolysis during brewing followed by the secondary digestion for MS has made the analysis and dat…
  • Resurrecting a p53 peptide activator - An enabling nanoengineering strategy for peptide therapeutics. [Journal Article]
    J Control Release. 2020 Jul 09 [Online ahead of print]He W, Yan J, … Lu W
  • Many high-affinity peptide antagonists of MDM2 and MDMX have been reported as activators of the tumor suppressor protein p53 with therapeutic potential. Unfortunately, peptide activators of p53 generally suffer poor proteolytic stability and low membrane permeability, posing a major pharmacological challenge to anticancer peptide drug development. We previously obtained several potent dodecameric…
  • Multi-protease analysis of Pleistocene bone proteomes. [Journal Article]
    J Proteomics. 2020 Jul 08 [Online ahead of print]Lanigan LT, Mackie M, … Welker F
  • Ancient protein analysis is providing new insights into the evolutionary relationships between hominin fossils across the Pleistocene. Protein identification commonly relies on the proteolysis of a protein extract using a single protease, trypsin. As with modern proteome studies, alternative or additional proteases have the potential to increase both proteome size and protein sequence recovery. T…
  • Bassoon inhibits proteasome activity via interaction with PSMB4. [Journal Article]
    Cell Mol Life Sci. 2020 Jul 10 [Online ahead of print]Montenegro-Venegas C, Fienko S, … Fejtova A
  • Proteasomes are protein complexes that mediate controlled degradation of damaged or unneeded cellular proteins. In neurons, proteasome regulates synaptic function and its dysfunction has been linked to neurodegeneration and neuronal cell death. However, endogenous mechanisms controlling proteasomal activity are insufficiently understood. Here, we describe a novel interaction between presynaptic s…
  • Effect of N-methylated and fatty acid conjugation on analogs of antimicrobial peptide Anoplin. [Journal Article]
    Eur J Pharm Sci. 2020 Jul 07 [Online ahead of print]Liu T, Zhu N, … Ni J
  • With the increment of drug-resistant bacteria and the slow development of novel antibiotics, antimicrobial peptides have gained increasing attention as a potential antibiotic alternative. They not only displayed a broad-spectrum antimicrobial activity but also were difficult to induce resistance development because of their unique membrane-lytic activity. Herein, to improve the limitations of Ano…
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