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344 results
  • Intraluminal prucalopride increases propulsive motor activities via luminal 5-HT4 receptors in the rabbit colon. [Journal Article]
  • NMNeurogastroenterol Motil 2019 Apr 23; :e13598
  • Shokrollahi M, Chen JH, Huizinga JD
  • CONCLUSIONS: Activating mucosal 5-HT4 receptors via intraluminal prucalopride or 5-HT increases propulsive motor activity in a graded manner; that is, depending on starting conditions, amplitudes or frequencies of an activity may increase or a new pattern may be initiated. Our data support further studies into delivering 5-HT4 receptor agonists via colon-targeted drug delivery systems and studies into the role of luminal 5-HT as an essential requirement for normal colon motor pattern generation.
  • Pharmaceutical Approval Update. [Journal Article]
  • P TP T 2019; 44(4):178-209
  • Kaufman MB
  • Motegrity (prucalopride) for chronic idiopathic constipation; Aemcolo (rifamycin) for travelers' diarrhea; and Dextenza (dexamethasone ophthalmic insert) for ocular pain after ophthalmic surgery.
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