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73 results
  • StatPearls: Pseudohyponatremia [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Theis Samuel R. SR Wright-Patterson AFB / Wright State Khandhar Paras B. PB Beaumont Health System BOOK
  • Pseudohyponatremia is an uncommonly encountered laboratory abnormality that is defined by a serum sodium concentration of less than 135 mEq/L in the setting of a normal serum osmolality (280 to 300 mOsm/kg). Conversely, true hyponatremia is associated with low serum osmolality and should prompt evaluation for the presence of an additional abnormal solute that may be affecting the laboratory asses…
  • Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020. [Review]
    Am J Kidney Dis. 2019 Oct 10 [Online ahead of print]Seay NW, Lehrich RW, Greenberg A
  • Overall body fluid concentration is regulated within a narrow range by the concerted action of the hypothalamic-pituitary axis to influence water intake through thirst and water excretion via the effect of vasopressin, or antidiuretic hormone, on renal collecting duct water permeability. Sodium is the principal extracellular cation; abnormalities in overall effective body fluid concentration, or …
  • Guillain-Barré syndrome hyponatremia: is it SIADH or pseudohyponatremia? [Case Reports]
    Oxf Med Case Reports. 2018 Jul; 2018(7):omy042.Zemke AM, Boles LH, … Viljoen JM
  • Approximately 5% of hospitalized patients with Guillain-Barré syndrome (GBS) experience SIADH; but pseudohyponatremia has also been reported in patients treated with IVIG. We present a case of a 51-year-old male with GBS who developed acute hyponatremia the day after initiation of IVIG; his sodium levels began to improve within 24 h of completion of IVIG. Differentiating between pseudohyponatremi…
  • Electrolytes: Sodium Disorders. [Review]
    FP Essent. 2017 Aug; 459:11-20.Braun MM, Mahowald M
  • Sodium disorders (ie, hyponatremia, hypernatremia) are common electrolyte disturbances in clinical medicine and are associated with increased rates of morbidity and mortality. Etiologies of hyponatremia are classified into four categories. The first is pseudohyponatremia, in which the sodium level is low due to hyperproteinemia, hyperlipidemia, or hyperglycemia. The other three categories are bas…
  • Recurrent syndrome of inappropriate antidiuretic hormone secretion due to tolterodine in an elderly male patient. [Case Reports]
    Saudi J Kidney Dis Transpl. 2017 May-Jun; 28(3):625-628.Alhwiesh AK, Alsharani H, … Abdurrahman IS
  • Hyponatremia is defined as serum sodium of <135 mmol/L and equates with a low serum osmolality once translocational hyponatremia and pseudohyponatremia are ruled out. True hyponatremia develops when normal urine-diluting mechanisms are disturbed. In elderly patients, this complication is not uncommon, especially in nursing homes and assisted living facilities. Medications are often the most commo…
  • Hypertriglyceridemic pancreatitis associated with confounding laboratory abnormalities. [Case Reports]
    J Community Hosp Intern Med Perspect. 2016; 6(3):31808.Melnick S, Nazir S, … Aryal MR
  • We present the case of a 36-year-old woman who presented to our hospital with epigastric abdominal pain and tenderness. Laboratory evaluation identified high lipase, normal amylase, pseudohyponatremia, and relatively falsely low triglyceride levels (initial value of 2,329 mg/dl which on repeat was found to have corrected value of >10,000 mg/dl). The overall clinical picture was consistent with ac…
  • Hyponatremia in patients with liver diseases: not just a cirrhosis-induced hemodynamic compromise. [Review]
    Hepatol Int. 2016 Sep; 10(5):762-72.Liamis G, Filippatos TD, … Elisaf MS
  • Hyponatremia (Na(+) <135 mmol/l) is the most common electrolyte disorder. Cirrhosis represents a rather frequent cause of hyponatremia mainly due to systemic and splanchnic vasodilation resulting in decreased effective arterial blood volume, which leads to excessive non-osmotic secretion of antidiuretic hormone. However, hyponatremia of multifactorial origin may be seen in patients with liver dis…
  • Ten common pitfalls in the evaluation of patients with hyponatremia. [Review]
    Eur J Intern Med. 2016 Apr; 29:22-5.Filippatos TD, Liamis G, … Elisaf MS
  • Hyponatremia is the most common electrolyte disorder in hospitalized patients associated with increased morbidity and mortality. On the other hand, inappropriate treatment of hyponatremia (under- or mainly overtreatment) may also lead to devastating consequences. The appropriate diagnosis of the causative factor is of paramount importance for the proper management and avoidance of treatment pitfa…
  • Asparaginase-Induced Hypertriglyceridemia Presenting as Pseudohyponatremia during Leukemia Treatment. [Journal Article]
    Case Rep Pediatr. 2014; 2014:635740.Hinson A, Newbern D, Linardic CM
  • Asparaginase is a chemotherapeutic agent used to induce disease remission in children with acute lymphoblastic leukemia (ALL). We describe the cases of two females with ALL who developed pseudohyponatremia as a presentation of hypertriglyceridemia following asparaginase treatment. Nine similar published cases of asparaginase-induced hypertriglyceridemia and its complications are also discussed. P…
  • Spurious electrolyte disorders: a diagnostic challenge for clinicians. [Review]
    Am J Nephrol. 2013; 38(1):50-7.Liamis G, Liberopoulos E, … Elisaf M
  • Spurious electrolyte disorders refer to an artifactually elevated or decreased serum electrolyte values that do not correspond to their actual systemic levels. When a clinician is confronted with a case of electrolyte disturbance, the first question should be whether it is an artifact. Spurious electrolyte disorders (pseudohyponatremia, pseudohypernatremia, pseudohypokalemia, pseudohyperkalemia, …
  • [Differential diagnosis and treatment of hyponatremia]. [Review]
    Vnitr Lek. 2013 Jun; 59(6):478-81.Mydlík M, Derzsiová K, Frank K
  • Hyponatremia is one of the most common metabolic disorders in clinical medicine. The value of Na+ in serum equalling 135 mmol/ l and lower is regarded as hyponatremia. Its clinical manifestations are the following: headaches, nausea, vomiting, seizures, numbness, coma and death. Hyponatremia caused by nonosmotic hypersecretion of vasopressin can be divided into: a) hypovolemic, b) normovolemic an…
  • Pseudohyponatremia in acute liver disease. [Case Reports]
    Am J Med Sci. 2013 Jan; 345(1):62-4.Vo H, Gosmanov AR, … Wall BM
  • Pseudohyponatremia secondary to hypercholesterolemia is a rare condition. In this study, the case of a 41-year-old woman who presented with acute hepatitis C virus infection and normal serum sodium and cholesterol concentrations is presented. Over the course of several weeks, she developed jaundice due to biopsy-confirmed intrahepatic cholestasis and severe hyponatremia, as measured by indirect p…
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