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(purple glove syndrome)
41 results
  • Why we prefer levetiracetam over phenytoin for treatment of status epilepticus. [Review]
    Acta Neurol Scand 2018; 137(6):618-622Zaccara G, Giorgi FS, … Tuscany study group on seizures in the emergency department and status epilepticus in adults
  • Over last fifty years, intravenous (iv) phenytoin (PHT) loading dose has been the treatment of choice for patients with benzodiazepine-resistant convulsive status epilepticus and several guidelines recommended this treatment regimen with simultaneous iv diazepam. Clinical studies have never shown a better efficacy of PHT over other antiepileptic drugs. In addition, iv PHT loading dose is a comple…
  • Fosphenytoin-induced purple glove syndrome: A case report. [Case Reports]
    Clin Neurol Neurosurg 2017; 160:50-53Newman JW, Blunck JR, … Croom JE
  • CONCLUSIONS: Early recognition and emergent management of PGS are key for optimal recovery. Although fosphenytoin has a significantly reduced risk of associated PGS compared to phenyotin, increased awareness for fosphenytoin-induce PGS can accelerate intervention and minimize morbidity of this rare yet detrimental adverse reaction.
  • Warfarin and phenytoin drug interaction with possible purple glove syndrome. [Case Reports]
    J Pharmacol Pharmacother 2016 Apr-Jun; 7(2):96-8Hunter CS, Phan SV
  • Though the impact of phenytoin on warfarin has been reported to potentiate the anticoagulant effect or interact in a biphasic manner, the effect of phenytoin on warfarin appears to be unpredictable and dependent upon multiple factors. Additionally, purple glove syndrome has rarely been reported secondary to therapeutic doses of oral phenytoin. We report on the case of a patient who experienced in…
  • An anaesthesiologist's encounter with purple glove syndrome. [Journal Article]
    Indian J Anaesth 2016; 60(3):199-201Uma B, Kochhar A
  • Purple glove syndrome (PGS) is a devastating complication of intravenous (IV) phenytoin administration. Anaesthetic management during the amputation of the limb for such patients is very challenging due to limited clinical experience. A 65-year-old woman developed PGS of left upper extremity after IV administration of phenytoin following generalised tonic-clonic seizures. The condition progressed…
  • Phenytoin-Induced Purple Glove Syndrome: A Case Report and Review of the Literature. [Journal Article]
    Hosp Pharm 2015; 50(5):391-5Okogbaa JI, Onor IO, … Lillis RA
  • CONCLUSIONS: The Naranjo Adverse Drug Reaction Probability Scale assigned a score of 7, indicating phenytoin as the probable cause of purple glove syndrome (PGS). The patient's PGS was managed with a combination of dry dressing material, left forearm elevation, collagenase topical cream, 0.1% IV bupivacaine, and IV fentanyl. The patient's injury was resolving at the time of discharge to a rehabilitation facility.PGS is a rare complication of IV phenytoin therapy. The risk of PGS for this patient may have been abated by decreasing the phenytoin infusion rate from 50 mg/min to less than 25 mg/min.
  • The safety and efficacy of fosphenytoin for the treatment of status epilepticus. [Journal Article]
    Expert Rev Neurother 2015; 15(9):983-92Popławska M, Borowicz KK, Czuczwar SJ
  • Fosphenytoin, a water-soluble prodrug of the antiepileptic drug phenytoin, is entirely and rapidly converted to this antiepileptic drug. The mechanism of action of fosphenytoin is related to the blockade of voltage-operated sodium channels. It was developed in order to obtain a phenytoin-like drug with improved water solubility. Its maximal plasma concentration is achieved within 90-190 min follo…
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