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21 results
  • NMR fragment-based screening for development of the CD44-binding small molecules. [Journal Article]
    Bioorg Chem 2019; 82:284-289Pustuła M, Czub M, … Holak TA
  • The cell-surface protein CD44, a primary receptor for hyaluronic acid (HA), is one of the most promising targets for cancer therapies. It is prominently involved in the process of tumor growth and metastasis. The possibility of modulating the CD44-HA interaction with a pharmacological inhibitor is therefore of great importance, yet until now there are only few small molecules reported to bind to …
  • Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity. [Journal Article]
    Int J Mol Sci 2018; 19(9)Chudzian J, Szlachcic A, … Otlewski J
  • Fibroblast growth factor 1 (FGF1) and its receptors (FGFRs) regulate crucial biological processes such as cell proliferation and differentiation. Aberrant activation of FGFRs by their ligands can promote tumor growth and angiogenesis in many tumor types, including lung or breast cancer. The development of FGF1-targeting molecules with potential implications for the therapy of FGF1-driven tumors i…
  • Identification of small-molecule inhibitors of USP2a. [Journal Article]
    Eur J Med Chem 2018; 150:261-267Tomala MD, Magiera-Mularz K, … Holak TA
  • USP2a is a deubiquitinating protease that rescues its target proteins from destruction by the proteasome by reversing the process of protein ubiquitination. USP2a shows oncogenic properties in vivo and has been found to be a specific activator of cyclin D1. Many types of cancers are addicted to cyclin D1 expression. Targeting USP2a is a promising strategy for cancer therapy but little progress ha…
  • Phylogenetic classification of yeasts and related taxa within Pucciniomycotina. [Journal Article]
    Stud Mycol 2015; 81:149-89Wang QM, Yurkov AM, … Bai FY
  • Most small genera containing yeast species in the Pucciniomycotina (Basidiomycota, Fungi) are monophyletic, whereas larger genera including Bensingtonia, Rhodosporidium, Rhodotorula, Sporidiobolus and Sporobolomyces are polyphyletic. With the implementation of the "One Fungus = One Name" nomenclatural principle these polyphyletic genera were revised. Nine genera, namely Bannoa, Cystobasidiopsis, …
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