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(qi ch'i)
50,940 results
  • Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis. [Journal Article]
    Exp Cell Res. 2020 Jul 09 [Online ahead of print]Chang H, Wang Y, … Qi Z
  • It has been reported that cholesterol-lowing agents can ameliorate severity of myocarditis. However, the beneficial effect of the agents has been claimed to be independent of cholesterol reduction as there is no significant change in the plasma cholesterol level in myocarditis. In the present study, using experimental autoimmune myocarditis (EAM) rats as an animal model, we demonstrated that EAM …
  • Chemical characteristics and sources of water-soluble organic aerosol in southwest suburb of Beijing. [Journal Article]
    J Environ Sci (China). 2020 Sep; 95:99-110.Hu R, Xu Q, … Hao J
  • PM2.5 filter sampling and components measurement were conducted in autumn and winter from 2014 to 2015 at a suburban site (referred herein as "LLH site") located in the southwest of Beijing. The offline aerosol mass spectrometry (offline-AMS) analysis and positive matrix factorization (PMF) were applied for measurement and source apportionment of water-soluble organic aerosol (WSOA). Organic aero…
  • One-step heating strategy for efficient solubilization of recombinant spider silk protein from inclusion bodies. [Journal Article]
    BMC Biotechnol. 2020 Jul 10; 20(1):37.Cai H, Chen G, … Qi X
  • CONCLUSIONS: The one-step heating method introduced here efficiently solubilizes IBs under relatively mild conditions compared to the traditional ones, which might be important for the downstream applications; however, this protocol should be pursued carefully in terms of urea-induced modification sensitive applications. Further, this method can be applied under broad buffer, pH and temperature conditions, conferring the potential to apply to other thermal stable proteins.
  • Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma. [Journal Article]
    Cell. 2020 Jul 09; 182(1):200-225.e35.Gillette MA, Satpathy S, … Clinical Proteomic Tumor Analysis Consortium
  • To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, co…
  • [Review and thinking of fifth national clinical skill competition of acupuncture-moxibustion and tuina]. [Journal Article]
    Zhongguo Zhen Jiu. 2020 Jul 12; 40(7):777-80.Zhou HJ, Wang H, … Qi FJ
  • Through the review and summary of the 5th national clinical skill competition of acupuncture-moxibustion and tuina, it is recognized that the strict security of training, the concentrated training items, active competition of training and the diversity of training patterns are the keys of achievement. Besides, the suggestions are proposed in terms of tuina manipulations and the recitation content…
  • Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer. [Journal Article]
    Cancer Res. 2020 Jul 09 [Online ahead of print]Li F, Ng WL, … Wong KK
  • Despite advancements in treatment options, the overall cure and survival rates for non-small cell lung cancers (NSCLC) remain low. While small-molecule inhibitors of epigenetic regulators have recently emerged as promising cancer therapeutics, their application in patients with NSCLC is limited. To exploit epigenetic regulators as novel therapeutic targets in NSCLC, we performed pooled epigenome-…
  • Feature Point Registration Model of Farmland Surface and Its Application Based on a Monocular Camera. [Journal Article]
    Sensors (Basel). 2020 Jul 07; 20(13)Li Y, Huang D, … Jia H
  • In this study, an image registration algorithm was applied to calculate the rotation angle of objects when matching images. Some commonly used image feature detection algorithms such as features from accelerated segment test (FAST), speeded up robust features (SURF) and maximally stable extremal regions (MSER) algorithms were chosen as feature extraction components. Comparing the running time and…
  • A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. [Journal Article]
    Cell. 2020 Jun 28 [Online ahead of print]Dai L, Zheng T, … Gao GF
  • Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited immunogenicity. We describe a dimeric form of MERS-CoV RBD that overcomes this limitation. The RBD-dimer significantly increased neutralizing antibody…
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