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(quantitative structure activity relationships)
15,963 results
  • Transitioning to composite bacterial mutagenicity models in ICH M7 (Q)SAR analyses. [Journal Article]
    Regul Toxicol Pharmacol 2019; :104488Landry C, Kim MT, … Stavitskaya L
  • The International Council on Harmonisation (ICH) M7(R1) guideline describes the use of complementary (quantitative) structure-activity relationship ((Q)SAR) models to assess the mutagenic potential of drug impurities in new and generic drugs. Historically, the CASE Ultra and Leadscope software platforms used two different statistical-based models to predict mutations at G-C (guanine-cytosine) and…
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