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153 results
  • Reintroduction of quazepam: an update on comparative hypnotic and adverse effects. [Journal Article]
    Int Clin Psychopharmacol 2019; 34(6):275-285Moniri NH
  • Insomnia is a prevalent disorder that affects over one-third of the U.S. population to varying degrees and is highly disruptive towards quality of life. Pharmacological treatments for insomnia include benzodiazepines (BZs) and the non-BZ 'Z-drugs' (zolpidem, zaleplon, eszopiclone, zopiclone), which are amongst the most widely prescribed medications. Yet, these agents can produce adverse effects s…
  • Drugs and Lactation Database (LactMed): Quazepam [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • No information is available on the long-term use of quazepam during breastfeeding. Because the drug and metabolites could accumulate in the breastfed infant, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.
  • An update of management of insomnia in patients with chronic orofacial pain. [Review]
    Oral Dis 2017; 23(8):1043-1051Almoznino G, Haviv Y, … Benoliel R
  • In this review, we discuss the management of chronic orofacial pain (COFP) patients with insomnia. Diagnostic work-up and follow-up routines of COFP patients should include assessment of sleep problems. Management is based on a multidisciplinary approach, addressing the factors that modulate the pain experience as well as insomnia and including both non-pharmacological and pharmacological modalit…
  • Review of Safety and Efficacy of Sleep Medicines in Older Adults. [Review]
    Clin Ther 2016; 38(11):2340-2372Schroeck JL, Ford J, … Mergenhagen KA
  • Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia.
  • Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. [Review]
    Pharmacol Rep 2016; 68(2):231-42Kumar A, Chanana P, Choudhary S
  • The pharmacological management of insomnia has lately become a challenge for researchers worldwide. As per the third International Classification of Sleep disorders (ICSD-3) insomnia can be defined as a state with repeated difficulty in sleep initiation, duration, consolidation, or quality that occurs despite adequate opportunity and circumstances for sleep, and results in some form of daytime im…
  • Structural analysis of quazepam metabolites in bile by ion trap time-of-flight mass spectrometry. [Journal Article]
    Forensic Sci Int 2015; 256:7-16Yamaguchi K, Goda T, … Ohno Y
  • Quazepam (QZP) is a long-acting benzodiazepine-type hypnotic. We searched for novel QZP metabolites in bile and determined their structures by liquid chromatography-ion trap time-of-flight mass spectrometry (LC-IT-TOF MS). The metabolites were extracted with ethyl acetate after β-glucuronidase treatment. First, a single MS spectrum was acquired. Second, MS(n) spectra were acquired for peaks that …
  • National use of prescription medications for insomnia: NHANES 1999-2010. [Journal Article]
    Sleep 2014; 37(2):343-9Bertisch SM, Herzig SJ, … Buettner C
  • CONCLUSIONS: In this nationally representative sample, reported use of prescription medications commonly used for insomnia (MCUFIs) within the preceding month was common, particularly among older adults and those seeing a mental health provider, with high use of sedative polypharmacy among MCUFI users.
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