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12,178 results
  • Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1. [Journal Article]
    Sci Rep. 2020 Jul 03; 10(1):11017.Schank JR, Lee S, … Choi I
  • The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO3 transporter NBCn1 suggest that this pH-regulating protein may affect alcohol-related behavior and response. Here, we examined alcohol consumption and sensitivity to the sedative effects of alcohol in male NBCn1 knockout mice. These mice displayed lower pH in neurons than wildtype controls, dete…
  • Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue. [Journal Article]
    Acta Physiol (Oxf). 2020 Jun 29 [Online ahead of print]Yasumatsu K, Ohkuri T, … Ninomiya Y
  • CONCLUSIONS: We found evidence for the contribution of SGLTs in sugar sensing in taste cells of mouse tongue. Moreover, we found T1R-dependent (Phl-insensitive) type, Glc-type and Mixed (SGLTs and T1Rs)-type fibres. SGLT1 may be involved in the latter two types and may play important roles in the glucose-specific cephalic phase of digestion and palatable food intake.
  • HbA1C levels: falsely low in a patient taking dapsone. [Letter]
    Clin Exp Dermatol. 2020 Jun 23 [Online ahead of print]Spring IR, Ilangaratne C, Walsh S
  • We write to highlight to colleagues an important clinical lesson regarding a drug-related side effect of dapsone use. A 50-year-old Caucasian male presented to the diabetes clinic in January 2019. He had taken dapsone (100mg daily) for control of dermatitis herpetiformis in the context of coeliac disease since 2011. He was diagnosed with type 1 diabetes aged 13 years and had a background of subop…
  • Systemic drug photosensitivity-Culprits, impact and investigation in 122 patients. [Journal Article]
    Photodermatol Photoimmunol Photomed. 2020 Jun 21 [Online ahead of print]Alrashidi A, Rhodes LE, … Ahad T
  • CONCLUSIONS: Classically described photosensitizing drugs such as thiazides and quinine remain common offenders, while emerging culprits include biologics such as TNF-a inhibitors and proton-pump-inhibitors. There is very large impact on life quality; identification facilitates measures including drug cessation and implementation of appropriate photoprotection.
  • Chloroquine in controlling biological infections. [Review]
    Pol Merkur Lekarski. 2020 Jun 17; 48(285):199-203.Płusa T, Lengier-Krajewska M, … Krawczyk J
  • From the middle of the 17th century, Cinchona tree's bark, which contains quinine, was used as an anti-malarial agent. It wasn't until the midtwentieth century that chloroquine was synthesized, followed by its further derivatives. Chloroquine inhibits protozoan polymerase activity, leading to an increase in heme, which is toxic to Plasmodium. The sensitivity of the protozoan to chloroquine depend…
  • The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders. [Review]
    Molecules. 2020 Jun 09; 25(11)Nyakudya TT, Tshabalala T, … Ndhlala AR
  • Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consu…
  • Altering salivary protein profile can decrease aversive oromotor responding to quinine in rats. [Journal Article]
    Physiol Behav. 2020 Jun 08 [Online ahead of print]Martin LE, Kay KE, … Torregrossa AM
  • Bitter taste is often associated with toxins, but accepting some bitter foods, such as green vegetables, can be an important part of maintaining a healthy diet. It has previously been shown that animals exposed to quinine upregulate a set of salivary proteins (SPs), and those with upregulated SPs have increased rates of feeding on a quinine diet as well as increased brief-access licking to and hi…
  • Impact of alkaloids in food consumption, metabolism and survival in a blood-sucking insect. [Journal Article]
    Sci Rep. 2020 Jun 10; 10(1):9443.Muñoz IJ, Schilman PE, Barrozo RB
  • The sense of taste provides information about the "good" or "bad" quality of a food source, which may be potentially nutritious or toxic. Most alkaloids taste bitter to humans, and because bitter taste is synonymous of noxious food, they are generally rejected. This response may be due to an innate low palatability or due to a malaise that occurs after food ingestion, which could even lead to dea…
  • Increased responding for alcohol and resistance to aversion in female mice. [Journal Article]
    Alcohol Clin Exp Res. 2020 May 29 [Online ahead of print]Sneddon EA, Ramsey OR, … Radke AK
  • CONCLUSIONS: Females respond more for EtOH at higher concentrations and continue to respond for 10% EtOH at all concentrations of quinine, suggesting that female mice are more motivated to respond for alcohol in an operant self-administration paradigm than males. Understanding behavioral and mechanistic sex differences in responding for alcohol will allow for the advancement of treatments for women with AUD.
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