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906 results
  • [Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment]. [Randomized Controlled Trial]
    Brain Nerve 2019; 71(9):943-952Takahashi S, Morimoto S, Okano H
  • We performed drug screening using motor neurons derived from disease-specific induced pluripotent stem cells (iPSCs) for amyotrophic lateral sclerosis (ALS) and found that ropinirole hydrochloride prevented motor neuron death. We have started a randomized clinical trial testing ropinirole hydrochloride in ALS patients in December 2018. This is a phase I/IIa randomized, double-blind, placebo-contr…
  • Rotigotine Transdermal Patch: A Review in Parkinson's Disease. [Journal Article]
    CNS Drugs 2019; 33(7):707-718Frampton JE
  • Rotigotine (Neupro®), a non-ergolinic dopamine agonist (DA), is administered once daily via a transdermal patch (TP) that delivers the drug over a 24-h period. In the EU, the rotigotine TP is approved as monotherapy for the treatment of early Parkinson's disease (PD) and as combination therapy with levodopa throughout the course of the disease. It is also approved for the treatment of PD in numer…
  • D3 receptor agonist efficacy in restless legs syndrome. [Journal Article]
    Adv Pharmacol 2019; 84:21-35Casoni F, Galbiati A, Ferini-Strambi L
  • Restless Legs Syndrome/Willis Ekbom Disease (RLS/WED) is a sleep related movement disorder characterized by an irresistible urge to move the limbs frequently associated with uncomfortable sensations that usually begin or worsen during inactivity and may be relieved by movement. The pathophysiology of the disorder involves several biological system; in particular, dopaminergic pathway and iron phy…
  • Quantitative Comparison of the Efficacies of 5 First-Line Drugs for Primary Restless Leg Syndrome. [Journal Article]
    J Clin Pharmacol 2019; 59(9):1177-1187Zhang N, Li Y, … Zheng Q
  • Comparative analyses of the efficacies of dopaminergic agonists (pramipexole, ropinirole, and rotigotine patch) and α-2-δ ligands (gabapentin enacarbil and pregabalin) for treatment of primary restless leg syndrome (RLS) are lacking because of the few head-to-head clinical trials. A model-based meta-analysis approach was employed to quantitatively compare the efficacies of these 5 first-line RLS …
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