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11,325 results
  • Impact of environmental pollution on PCDD/F and PCB bioaccumulation in game animals. [Journal Article]
    Environ Pollut 2019; 255(Pt 1):113159Warenik-Bany M, Maszewski S, … Piskorska-Pliszczynska J
  • Elucidation of the relationship between the levels of 35 individual dioxins and polychlorinated biphenyl congeners in environmental samples (pine needles, leaves, grass and soil), and their bioaccumulation in the muscles of two game animal families (Cervidae and Suidae) was the aim of the research. Comparative studies were performed in four industrially degraded regions with various types of heav…
  • Clinical and epidemiological observations on individual radiation sensitivity and susceptibility. [Journal Article]
    Int J Radiat Biol 2019; :1-16Seibold P, Auvinen A, … Blettner M
  • CONCLUSIONS: The authors conclude with the following recommendations for the way forward in radiation research: (a) there is need for large (prospective) cohort studies; (b) build upon existing radiation research cohorts; (c) use data from well-defined cohorts with good exposure assessment and biological material already collected; (d) focus on study quality with standardized data collection and reporting; (e) improve statistical analysis; (f) cooperation between radiobiology and epidemiology; and (g) take consequences of radiosensitivity and radiosusceptibility into account.
  • Analyzing expression and phosphorylation of the EGF receptor in HNSCC. [Journal Article]
    Sci Rep 2019; 9(1):13564Kriegs M, Clauditz TS, … Münscher A
  • Overexpression of the epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinomas (HNSCC) is considered to cause increased EGFR activity, which adds to tumorigenicity and therapy resistance. Since it is still unclear, whether EGFR expression is indeed associated with increased activity in HNSCC, we analyzed the relationship between EGFR expression and auto-phosphorylation as…
  • The efficacy and safety of amifostine for the acute radiation syndrome. [Journal Article]
    Expert Opin Drug Saf 2019; :1-14Singh VK, Seed TM
  • Introduction: A radiation countermeasure that can be used prior to radiation exposure to protect the population from the harmful effects of radiation exposure remains a major unmet medical need and is recognized as an important area for research. Despite substantial advances in the research and development for finding nontoxic, safe, and effective prophylactic countermeasures for the acute radiat…
  • Analysis of hypoxia in human glioblastoma tumors with dynamic 18F-FMISO PET imaging. [Journal Article]
    Australas Phys Eng Sci Med 2019Abdo RA, Lamare F, … Bentourkia M
  • Gliomas are the most common type of primary brain tumors and are classified as grade IV. Necrosis and hypoxia are essential diagnostic features which result in poor prognosis of gliomas. The aim of this study was to report quantitative temporal analyses aiming at determining the hypoxic regions in glioblastoma multiforme and to suggest an optimal time for the clinical single scan of hypoxia. Nine…
  • What Drosophila Can Teach Us About Radiation Biology of Human Cancers. [Review]
    Adv Exp Med Biol 2019; 1167:225-236Su TT
  • Ionizing radiation (IR) is used to treat more than half of human cancer patients. The therapeutic effect of IR is due to its ability to induce apoptosis. Success of radiation therapy relies not only on apoptosis induction but also on whether surviving cancer cells proliferate and regenerate a tumor. Drosophila melanogaster is a premier genetic model and, relevant to radiation biology of cancer, D…
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