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97 results
  • HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis. [Journal Article]
    Cell Mol Gastroenterol Hepatol. 2018; 5(1):15-30.Toullec A, Buard V, … Milliat F
  • CONCLUSIONS: We demonstrate in vivo that HIF-1α impacts radiation-induced enteritis and that this role differs according to the targeted cell type. Our work provides a new role for HIF-1α and endothelium-dependent mechanisms driving inflammatory processes in gut mucosae. Results presented show that effects on normal tissues have to be taken into account in approaches aiming to modulate hypoxia or hypoxia-related molecular mechanisms.
  • Trachycladines and Analogues: Synthesis and Evaluation of Anticancer Activity. [Journal Article]
    ChemMedChem. 2017 03 17; 12(6):448-455.Peitsinis ZV, Mitrakas AG, … Koumbis AE
  • The synthesis of four new analogues of marine nucleoside trachycladine A was accomplished by direct regio- and stereoselective Vorbrüggen glycosylations of 2,6-dichloropurine and 2-chloropurine with a d-ribose-derived chiron. Naturally occurring trachycladines A and B and a series of analogues were examined for their cytotoxic activity against a number of cancer cell lines (glioblastoma, lung, an…
  • Size-capacity mismatch in the lung: a novel predictor for complications after lung cancer surgery. [Journal Article]
    J Surg Res. 2017 03; 209:131-138.Murakami J, Ueda K, … Hamano K
  • CONCLUSIONS: Lung size-function mismatch was identified as the best predictor for cardiopulmonary complications after major lung resection for cancer among various spirometry- and CT-derived parameters. The usefulness of this parameter in screening for patients who are at risk of complications should be validated by a multicenter, large-scale study because it can be obtained through routine preoperative work.
  • Immunomodulation of classical and non-classical HLA molecules by ionizing radiation. [Review]
    Cell Immunol. 2016 May; 303:16-23.Gallegos CE, Michelin S, … Carosella ED
  • Radiotherapy has been employed for the treatment of oncological patients for nearly a century, and together with surgery and chemotherapy, radiation oncology constitutes one of the three pillars of cancer therapy. Ionizing radiation has complex effects on neoplastic cells and on tumor microenvironment: beyond its action as a direct cytotoxic agent, tumor irradiation triggers a series of alteratio…
  • In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury. [Journal Article]
    Sci Rep. 2015 Oct 29; 5:15738.Rannou E, François A, … Milliat F
  • The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an endothelium-dependent mechanism. We investigated whether endothelial-specific PAI…
  • Assessment of volume reduction effect after lung lobectomy for cancer. [Journal Article]
    J Surg Res. 2015 Jul; 197(1):176-82.Ueda K, Murakami J, … Hamano K
  • CONCLUSIONS: A combined assessment using spirometry and quantitative computed tomography helped to characterize the respiratory dynamics underlying the volume reduction effect, thus leading to the identification of novel predictors of a volume reduction effect after lobectomy for cancer. Verification of our results by a large-scale prospective study may help to extend the indications for lobectomy in patients with oncologically resectable lung cancer who have a marginal pulmonary function.
  • Radiobiology of tissue reactions. [Journal Article]
    Ann ICRP. 2015 Jun; 44(1 Suppl):58-68.Dörr W
  • Tissue effects of radiation exposure are observed in virtually all normal tissues, with interactions when several organs are involved. Early reactions occur in turnover tissues, where proliferative impairment results in hypoplasia; late reactions, based on combined parenchymal, vascular, and connective tissue changes, result in loss of function within the exposed volume; consequential late effect…
  • Evaluation of the alamarblue assay for adherent cell irradiation experiments. [Journal Article]
    Dose Response. 2014 May; 12(2):246-58.Zachari MA, Chondrou PS, … Koukourakis MI
  • The AlamarBlue assay is based on fluorometric detection of metabolic mitochondrial activity of cells. In this study, we determined the methodology for application of the assay to radiation response experiments in 96-well plates. AlamarBlue was added and its reduction measured 7 hours later. Selection of the initial number of plated cells was important so that the number of proliferating cells rem…
  • Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology. [Review]
    Biomarkers. 2014 May; 19(3):167-80.Pouliliou S, Koukourakis MI
  • Ionizing radiation cause DNA damage to cells, leading them to cell death via DNA double-strand breaks (DSBs) formation. DSBs formation is followed immediately by histone H2AX phosphorylation (γ-H2AX) and multitude repair factors accumulation. Here we present the methods and the bio-sampling for γ-H2AX detection, γ-H2AX formation in normal cells and animal tissues, in cancer cell lines/tissues and…
  • Flagellin and LPS each restores rat lymphocyte populations after colorectal irradiation. [Journal Article]
    J Leukoc Biol. 2014 Jun; 95(6):931-40.Lacave-Lapalun JV, Benderitter M, Linard C
  • Radiation-induced gastrointestinal toxicity, including its shift of the immune balance, remains a major limitation to delivering tumoricidal doses of abdominal radiation therapy. This study evaluates the effect on the colon's innate and adaptive immune responses to moderate irradiation doses and the therapeutic possibilities of maintaining immune homeostasis. We investigated whether administratio…
  • HLA-G1 increases the radiosensitivity of human tumoral cells. [Journal Article]
    Cell Immunol. 2014 Feb; 287(2):106-11.Gallegos CE, Michelin S, … Carosella ED
  • Different molecules regulate the response of tumoral tissues to ionizing radiation. The objective of this work was to determine if HLA-G1 expression modulates the radiosensitivity of human tumoral cell lines. To this end, human melanoma M8 and human erythroleukemia K562 cell lines, with their correspondent HLA-G1 negative and positive variants, were gamma irradiated and the survival frequency was…
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