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97 results
  • HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis. [Journal Article]
    Cell Mol Gastroenterol Hepatol 2018; 5(1):15-30Toullec A, Buard V, … Milliat F
  • CONCLUSIONS: We demonstrate in vivo that HIF-1α impacts radiation-induced enteritis and that this role differs according to the targeted cell type. Our work provides a new role for HIF-1α and endothelium-dependent mechanisms driving inflammatory processes in gut mucosae. Results presented show that effects on normal tissues have to be taken into account in approaches aiming to modulate hypoxia or hypoxia-related molecular mechanisms.
  • Trachycladines and Analogues: Synthesis and Evaluation of Anticancer Activity. [Journal Article]
    ChemMedChem 2017; 12(6):448-455Peitsinis ZV, Mitrakas AG, … Koumbis AE
  • The synthesis of four new analogues of marine nucleoside trachycladine A was accomplished by direct regio- and stereoselective Vorbrüggen glycosylations of 2,6-dichloropurine and 2-chloropurine with a d-ribose-derived chiron. Naturally occurring trachycladines A and B and a series of analogues were examined for their cytotoxic activity against a number of cancer cell lines (glioblastoma, lung, an…
  • Size-capacity mismatch in the lung: a novel predictor for complications after lung cancer surgery. [Journal Article]
    J Surg Res 2017; 209:131-138Murakami J, Ueda K, … Hamano K
  • CONCLUSIONS: Lung size-function mismatch was identified as the best predictor for cardiopulmonary complications after major lung resection for cancer among various spirometry- and CT-derived parameters. The usefulness of this parameter in screening for patients who are at risk of complications should be validated by a multicenter, large-scale study because it can be obtained through routine preoperative work.
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