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94,633 results
  • Advances in Targeted Alpha Therapy for Prostate Cancer. [Journal Article]
    Ann Oncol 2019De Vincentis G, Gerritsen W, … Sartor O
  • CONCLUSIONS: The described clinical benefit, safety and tolerability of radium-223 and the recent progress in TαT trial development suggest that TαT occupies an important new role in prostate cancer treatment. Ongoing studies with newer dosimetry methods, PSMA targeting, and novel approaches to combination therapies should expand the utility of TαT in prostate cancer treatment.
  • Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells. [Journal Article]
    Cancer Immunol Immunother 2019Koristka S, Ziller-Walter P, … Bachmann MP
  • Although CAR T-cell therapy has demonstrated tremendous clinical efficacy especially in hematological malignancies, severe treatment-associated toxicities still compromise the widespread application of this innovative technology. Therefore, developing novel approaches to abrogate CAR T-cell-mediated side effects is of great relevance. Several promising strategies pursue the selective antibody-bas…
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