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Unbound Medicine.
(radiopharmaceutical)
97,640 results
  • SPECT/CT - standing on the shoulders of giants, it is time to reach for the sky! [Journal Article]
    J Nucl Med. 2020 Jul 03 [Online ahead of print]Van den Wyngaert T, Elvas F, … Israel O
  • Twenty years ago single photon emission computed tomography/x-ray computed tomography (SPECT/CT) became commercially available, combining the strengths of both techniques: the diagnostic sensitivity of SPECT and the anatomic detail of CT. Other benefits initially included attenuation correction of SPECT reconstructions, ultimately evolving to correction techniques that would enable absolute trace…
  • The Role of PET-CT Imaging in Prostate Cancer. [Journal Article]
    Semin Ultrasound CT MR. 2020 Aug; 41(4):373-391.Subesinghe M, Kulkarni M, Cook GJ
  • Prostate cancer is the commonest malignancy to affect men in the United Kingdom. Extraprostatic disease detection at staging and in the setting of biochemical recurrence is essential in determining treatment strategy. Conventional imaging including computed tomography and bone scintigraphy are limited in their ability to detect sites of loco-regional nodal and metastatic bone disease, particularl…
  • First-Generation Bispidine Chelators for 213 BiIII Radiopharmaceutical Applications. [Journal Article]
    ChemMedChem. 2020 Jul 02 [Online ahead of print]Bruchertseifer F, Comba P, … Wadepohl H
  • Hepta- and octadentate bispidines (3,7-diazabicyclo[3.3.1]nonane, diaza-adamantane) with acetate, methyl-pyridine, and methyl-picolinate pendant groups at the amine donors of the bispidine platform have been prepared and used to investigate BiIII coordination chemistry. Crystal structure and solution spectroscopic data (NMR spectroscopy and mass spectrometry) confirm that the rigid and relatively…
  • Establishment of a clinical SPECT/CT protocol for imaging of 161Tb. [Journal Article]
    EJNMMI Phys. 2020 Jul 01; 7(1):45.Marin I, Rydèn T, … Bernhardt P
  • CONCLUSIONS: SPECT with high resolution is feasible with 161Tb; however, extrinsic uniformity correction is recommended to avoid ring artifacts. The LEHR collimator was the best choice of the three tested to obtain a high-resolution image. Due to the complex emission spectrum of low-energy photons, window-based scatter correction had a minor impact on the image quality compared to using attenuation correction only. On the other hand, performing attenuation, scatter, and collimator-detector correction clearly improved image quality. Based on these data, SPECT-based dosimetry for 161Tb-labeled radiopharmaceuticals is feasible.
  • Fifty Years of Radiopharmaceuticals. [Journal Article]
    J Nucl Med Technol. 2020 06; 48(Suppl 1):34S-39S.Brugarolas P, Comstock J, … Society of Nuclear Medicine and Molecular Imaging Radiopharmaceutical Sciences Council
  • To celebrate the 50th anniversary of the founding of the SNMMI Technologist Section in 1970, the Radiopharmaceutical Sciences Council board of directors is pleased to contribute to this celebratory supplement of the Journal of Nuclear Medicine Technology with a perspective highlighting major developments in the radiopharmaceutical sciences that have occurred in the last 50 years.
  • Zeolites for theranostic applications. [Review]
    J Mater Chem B. 2020 Jun 30 [Online ahead of print]Khodadadi Yazdi M, Zarrintaj P, … Mozafari M
  • Theranostic platforms bring about a revolution in disease management. During recent years, theranostic nanoparticles have been utilized for imaging and therapy simultaneously. Zeolites, because of their porous structure and tunable properties, which can be modified with various materials, can be used as a delivery agent. The porous structure of a zeolite enables it to be loaded and unloaded with …
  • A search of a quantitative quantum-chemical approach for radiolytic stability prediction. [Journal Article]
    Phys Chem Chem Phys. 2020 Jun 29 [Online ahead of print]Smirnova A, Mitrofanov A, … Petrov V
  • Radiolytic stability is one of the main requirements of the substances that are used in the chemistry of nuclear cycle or in the radiopharmaceutical chemistry. Herein, we proposed an approach for the prediction of radiolytic stability by the estimation of the molecular reactivity. The DFT calculations of the atom-wise reactivity descriptor were made for a number of organic molecules. The theoreti…
  • Non-FDG PET/CT. [Journal Article]
    Recent Results Cancer Res. 2020; 216:669-718.Lopci E, Fanti S
  • The major applications for molecular imaging with PET in clinical practice concern cancer imaging. Undoubtedly, 18F-FDG represents the backbone of nuclear oncology as it remains so far the most widely employed positron emitter compound. The acquired knowledge on cancer features, however, allowed the recognition in the last decades of multiple metabolic or pathogenic pathways within the cancer cel…
  • FDG PET Hybrid Imaging. [Journal Article]
    Recent Results Cancer Res. 2020; 216:625-667.Becker J, Schwarzenböck SM, Krause BJ
  • Molecular imaging with positron emission tomography (PET) using tumour-seeking radiopharmaceuticals has gained wide acceptance in oncology with many clinical applications. The hybrid imaging modality PET/CT (computed tomography) allows assessing molecular as well as morphologic information at the same time. Therefore, PET/CT represents an efficient tool for whole-body staging and re-staging withi…
  • Preclinical SPECT and SPECT-CT in Oncology. [Journal Article]
    Recent Results Cancer Res. 2020; 216:359-404.Franc BL, Seo Y, … Aparici CM
  • Molecular imaging enables both spatial and temporal understanding of the complex biologic systems underlying carcinogenesis and malignant spread. Single-photon emission tomography (SPECT) is a versatile nuclear imaging-based technique with ideal properties to study these processes in vivo in small animal models, as well as to identify potential drug candidates and characterize their antitumor act…
  • 18F-Labeled Small-Molecule and Low-Molecular-Weight PET Tracers for the Noninvasive Detection of Cancer. [Journal Article]
    Recent Results Cancer Res. 2020; 216:283-318.Waldmann CM, Kopka K, Wagner S
  • Noninvasive molecular imaging of cancer by means of the scintigraphic imaging modalities PET, PET/CT, and PET/MRI represents a powerful diagnostic tool in modern nuclear medicine. Radiotracers labeled with the prominent positron emitter fluorine-18 are routinely used to target and visualize discrete biological structures dysregulated in the progression of cancer. Such tracers are therefore capabl…
  • Single Photon Emission Computed Tomography Tracer. [Journal Article]
    Recent Results Cancer Res. 2020; 216:227-282.Pietzsch HJ, Mamat C, … Schibli R
  • Single photon emission computed tomography (SPECT) is the state-of-the-art imaging modality in nuclear medicine despite the fact that only a few new SPECT tracers have become available in the past 20 years. Critical for the future success of SPECT is the design of new and specific tracers for the detection, localization, and staging of a disease and for monitoring therapy. The utility of SPECT im…
  • Characterization of a preclinical PET insert in a 7 Tesla MRI scanner: beyond NEMA testing. [Journal Article]
    Phys Med Biol. 2020 Jun 26 [Online ahead of print]Gsell W, Molinos C, … González Martínez AJ
  • This study evaluates the performance of the Bruker PET insert combined with a BioSpec70/30 USR MRI scanner using the manufacturer acceptance protocol and the NEMA NU4-2008 for small animal positron emission tomographs (PET). The PET insert is made of 3 rings of 8 monolithic LYSO crystals (50x50x10 mm3) coupled to silicon photomultipliers (SiPM) arrays, conferring an axial and transaxial FOV of 15…
  • Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. [Journal Article]
    Cell Metab. 2020 Jun 22 [Online ahead of print]Gnad T, Navarro G, … Pfeifer A
  • The combination of aging populations with the obesity pandemic results in an alarming rise in non-communicable diseases. Here, we show that the enigmatic adenosine A2B receptor (A2B) is abundantly expressed in skeletal muscle (SKM) as well as brown adipose tissue (BAT) and might be targeted to counteract age-related muscle atrophy (sarcopenia) as well as obesity. Mice with SKM-specific deletion o…
  • Development of a Fully Automated Low Pressure [11 C]CO Carbonylation Apparatus. [Journal Article]
    J Labelled Comp Radiopharm. 2020 Jun 25 [Online ahead of print]Ferrat M, El Khoury Y, … Schou M
  • [11 C]Carbon monoxide ([11 C]CO) is a versatile synthon for radiolabeling of druglike molecules for imaging studies with positron emission tomography (PET). We here report the development of a novel, user-friendly, fully automated and good manufacturing practice compliant low pressure synthesis module for 11 C-carbonylation reactions using [11 C]CO. In this synthesis module, [11 C]CO was reliably…
  • Cholecystokinin-2 receptor targeting with radiolabeled peptides: current status and future directions. [Journal Article]
    Curr Med Chem. 2020 Jun 25 [Online ahead of print]Klingler M, Hörmann AA, Guggenberg EV
  • A wide variety of radiolabeled peptide analogs for specific targeting of cholecystokinin-2 receptors has been developed in the last decades. Peptide probes based on the natural ligands minigastrin (MG) and cholecystokinin (CCK) have high potential for molecular imaging and targeted radiotherapy of different human tumors, such as medullary thyroid carcinoma (MTC) and small cell lung cancer (SCLC).…
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