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2,632 results
  • [Pheochromocytoma and paraganglioma : Importance of diagnostic imaging]. [Review]
    Radiologe. 2019 Nov; 59(11):975-981.Kunz WG, Auernhammer CJ, … Cyran CC
  • If pheochromocytoma (PC) or paraganglioma (PGL) is diagnosed based on serologic studies, imaging is required to locate the adrenal mass for further management. Besides pathognomonic hormonal findings, PC/PGL can exhibit typical imaging features. However, PC/PGL can also show morphological overlap with other pathologies.
  • Sustained partial remission of a metastatic NEN using off-label immunotherapy with pembrolizumab. [Case Reports]
    Oncotarget. 2019 May 14; 10(35):3302-3311.Stüven AK, Wiedenmann B
  • Neuroendocrine neoplasms (NEN) are a heterogeneous group of tumors, which can be histologically separated by primary location, proliferation rate and differentiation of tumor cells. The therapeutic options and outcome depend on grading, staging and resectability of the tumor. Established treatment options of neuroendocrine tumors (NET) and carcinomas (NEC) are based especially on surgery, tumor s…
  • 111In-DTPA-d-Phe-1-Asp0-d-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-d-Phe1-octreotide. [Journal Article]
    Nucl Med Biol. 2017 Nov; 54:18-26.Oshima N, Akizawa H, … Ohkura K
  • CONCLUSIONS: 111In-DTPA-d-Phe-1-Asp0-d-Phe1-octreotide exhibited higher tumor accumulation and persistence of tumor radioactivity than 111In-DTPA-d-Phe1-octreotide. We reasoned that this higher tumor accumulation would not be based on the receptor affinity but on a receptor-mediated endocytotic process involved in temperature-dependent cellular uptake. The present study demonstrated the great potential of the pharmaceutical development of a new radiolabeled peptide with high tumor accumulation and low renal radioactivity by the chemical modification of 111In-DTPA-d-Phe1-octreotide.
  • Expression of Bioactive Callithrix jacchus Follicle-Stimulating Hormone in Pichia pastoris. [Journal Article]
    Appl Biochem Biotechnol. 2015 May; 176(2):399-411.Kutteyil SS, Pathak BR, … Mahale SD
  • Callithrix jacchus (common marmoset) is a New World primate monkey, used as an animal model in biomedical research. Marmoset-specific follicle-stimulating hormone (FSH) preparation is required to improve superovulation protocols and to develop homologous FSH monitoring assays in these monkeys. In this study, we document the large-scale expression of recombinant marmoset FSH in methylotropic yeast…
  • Synthesis of [³²P]NAADP for the radioreceptor binding assay. [Journal Article]
    Cold Spring Harb Protoc. 2014 Sep 02; 2014(9):993-5.Galione A, Chuang KT, … Churchill GC
  • Nicotinic acid adenine dinucleotide phosphate (NAADP) is a major messenger for Ca(2+) mobilization in cells. NAADP-binding proteins are highly selective and have a strong affinity for NAADP. This is the basis of the radioreceptor binding assay, which is used to measure NAADP levels in cells and tissues and to identify cellular stimuli that use NAADP as an intracellular messenger. In the radiorece…
  • [The adverse effects of anticholinergic drugs]. [Review]
    Brain Nerve. 2014 May; 66(5):551-60.Iwaki H, Nomoto M
  • Acetylcholine is one of the main neurotransmitters. It is involved in autonomic activities of the peripheral organs and forms a part of complicated neural networks in the central nervous system. Anticholinergic drugs are used in the treatment of various diseases, and many drugs have anticholinergic side effects. Thus, estimating the total burden of anticholinergic activity of drugs is important t…
  • Measurement of phospholipid metabolism in intact neutrophils. [Journal Article]
    Methods Mol Biol. 2014; 1124:89-105.Sergeant S, McPhail LC
  • Phospholipid-metabolizing enzymes are important participants in neutrophil signal transduction pathways. The methods discussed herein describe assays for assessing the activities of phospholipase A2 (PLA2), phospholipase C (PLC), phospholipase D (PLD), and phosphoinositide 3-OH-kinase in intact neutrophils. PLA2 activity is measured as the release of radiolabeled arachidonic acid. PLC activity is…
  • Placental calcitriol synthesis and IGF-I levels in normal and preeclamptic pregnancies. [Review]
    J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:44-9.Halhali A, Díaz L, … Larrea F
  • Placenta is an extrarenal source of calcitriol and pregnancy is associated with increased maternal serum levels of this hormone. It has been reported that insulin-like growth factor I (IGF-I) stimulates placental calcitriol synthesis and that circulating levels of both hormones are low in preeclampsia. Since calcitriol production has not been determined in placental homogenates in preeclampsia, t…
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