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(raloxifene)
3,822 results
  • Effects of ospemifene on bone in postmenopausal women. [Journal Article]
  • CClimacteric 2019 Jul 11; :1-6
  • de Villiers TJ, Altomare C, … Gambacciani M
  • Ospemifene is a selective estrogen-receptor modulator approved for treating menopause-related moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy (VVA), in the United…
  • Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review [BOOK]
  • BOOKAgency for Healthcare Research and Quality (US): Rockville (MD)
  • Fink HA, MacDonald R, … Wilt TJ
  • CONCLUSIONS: Long-term alendronate, zoledronate, and oral hormone therapy reduced nonvertebral fractures in older women, with oral hormone therapy also reducing hip fractures. While absolute reductions in typical fractures with long-term bisphosphonates are large relative to increases in AFF, reduced hip fracture risk with oral hormone therapy appears offset by increased risk of serious harms. Evidence is limited regarding ODT holidays for fractures and harms. Future research is needed, including randomized trials comparing ODT holiday durations and sequential treatments powered for clinical fractures, and controlled cohort studies of ODT holidays to estimate rare harms.
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