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3,620 results
  • Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects. [Journal Article]
  • BPBMC Pharmacol Toxicol 2017 Apr 28; 18(1):18
  • Chartier M, Morency LP, … Najmanovich RJ
  • CONCLUSIONS: The detection of molecular interaction field similarities provide the opportunity to suggest drug repurposing opportunities as well as to identify potential molecular mechanisms responsible for side-effects. All methods utilized are freely available and can be readily applied to new query binding-sites. All data is freely available and represents an invaluable source to identify further candidates for repurposing and suggest potential mechanisms responsible for side-effects.
  • A peek into the drug development scenario of endometriosis - A systematic review. [Review]
  • BPBiomed Pharmacother 2017 Apr 10; 90:575-585
  • Goenka L, George M, Sen M
  • CONCLUSIONS: From the literature review, it appears that the most promising molecules for the treatment of endometriosis in the near future include elagolix, mifepristone, TAK-385, KLH-2109 and ASP1707 and cabergoline. It remains to be seen if these molecules would succeed large phase 3 clinical trials and overcome the regulatory hurdles to become an essential tool in the gynaecologist's armamentarium against endometriosis.
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