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370 results
  • Cardioprotective Melatonin: Translating from Proof-of-Concept Studies to Therapeutic Use. [Review]
    Int J Mol Sci 2019; 20(18)Baltatu OC, Senar S, … Cipolla-Neto J
  • In this review we summarized the actual clinical data for a cardioprotective therapeutic role of melatonin, listed melatonin and its agonists in different stages of development, and evaluated the melatonin cardiovascular target tractability and prediction using machine learning on ChEMBL. To date, most clinical trials investigating a cardioprotective therapeutic role of melatonin are in phase 2a.…
  • Clinical Therapeutic Strategy and Neuronal Mechanism Underlying Post-Traumatic Stress Disorder (PTSD). [Review]
    Int J Mol Sci 2019; 20(15)Yabuki Y, Fukunaga K
  • Post-traumatic stress disorder (PTSD) is characterized by an exaggerated response to contextual memory and impaired fear extinction, with or without mild cognitive impairment, learning deficits, and nightmares. PTSD is often developed by traumatic events, such as war, terrorist attack, natural calamities, etc. Clinical and animal studies suggest that aberrant susceptibility of emotion- and fear-r…
  • Advances of Melatonin-Based Therapies in the Treatment of Disturbed Sleep and Mood. [Journal Article]
    Handb Exp Pharmacol 2019; 253:305-319Alston M, Cain SW, Rajaratnam SMW
  • Melatonin and melatonin agonists offer novel treatments for sleep and mood disorders, particularly where circadian misalignment is also present. The therapies offer both phase-shifting and sleep-promoting effects and have shown potential to treat advanced and delayed sleep-wake phase disorder, non-24-h sleep-wake cycle, jetlag, shift work disorder, insomnia, seasonal affective disorder and major …
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