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(rasburicase)
404 results
  • Current understanding of tumor lysis syndrome. [Review]
    Hematol Oncol 2019Rahmani B, Patel S, … Khan SA
  • Tumor lysis syndrome (TLS) is an oncologic emergency from the intracellular release of material in lysing malignant cells. The earlier it is treated, the less likely it is to be harmful to an individual and spread through the body. Common complications of TLS include arrhythmias, which are caused by hypocalcemia or hyperkalemia, renal failures due to hyperuricemia or hyperphosphatemia, and seizur…
  • Spontaneous Tumor Lysis Syndrome in Diffuse Large B-cell Lymphoma: Early Diagnosis and Management. [Case Reports]
    Cureus 2019; 11(5):e4679Gangireddy M, Shrimanker I, … Peroutka KA
  • Spontaneous tumor lysis syndrome is a rare oncological emergency associated with multiorgan failure. It is characterized by an elevation of uric acid, hyperphosphatemia, hypocalcemia, hyperkalemia and renal failure in the setting of no active chemotherapy as a result of lysis of massive tumor burden. Early recognition of the disease and prompt management would affect morbidity and mortality. We p…
  • Impact of early rasburicase on incidence of clinical tumor lysis syndrome in lymphoma. [Journal Article]
    Leuk Lymphoma 2019; 60(9):2271-2277Personett HA, Barreto EF, … Habermann TM
  • Early administration of rasburicase to enhance uric acid (UA) elimination has been adopted without robust evidence in support of its impact on clinical outcomes in tumor lysis syndrome (TLS), specifically, the prevention of acute kidney injury (AKI). This was a retrospective cohort study of adult lymphoma patients at intermediate or high risk for TLS. Excluded patients had AKI or were on dialysis…
  • Erythrodermic Psoriasis Causing Uric Acid Crystal Nephropathy. [Case Reports]
    Case Rep Med 2019; 2019:8165808Ellis J, Lew J, … Denunzio T
  • CONCLUSIONS: This case presents the rare complication of crystal-induced nephropathy in a patient with erythrodermic psoriasis. Uric acid crystal nephropathy is well described in diseases with rapid cell turnover such as tumor lysis syndrome. It is thought that rapid keratinocyte differentiation and inflammatory infiltration of psoriatic lesions produced life-threatening electrolyte abnormalities similar to tumor lysis syndrome. Early recognition of this rare complication is critical, and aggressive fluid resuscitation, urine alkalinization, and uric acid lowering agents should be administered immediately.
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