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1,504 results
  • Inhibition of JAK/STAT signaling in rheumatologic disorders: the expanding spectrum. [Journal Article]
    Joint Bone Spine 2019Jammal TE, Gerfaud-Valentin M, … Jamilloux Y
  • Three Janus kinase (JAK) inhibitors, ruxolitinib, tofacitinib, and baricitinib, are currently approved by the FDA/EMA for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative rectocolitis. The inhibition of JAK/STAT signaling by these small molecules, downstream of several cytokine receptors, results in lower pro-inflammatory gene expression. Given the cytokine profiles obse…
  • Endoscopic and clinicopathological characteristics of gastrointestinal adult T-cell leukemia/lymphoma. [Journal Article]
    J Gastrointest Oncol 2019; 10(4):723-733Ishibashi H, Nimura S, … Takeshita M
  • CONCLUSIONS: ATLL predominantly involves the stomach. Leukemic behavior of ATLL had a large influence on the tumor location and endoscopic features of GI tract lesions. Gastropathy-, enteropathy-, and proctocolitis-like lesions showed additional distinct characteristics. Primary GI ATLL in the early clinical stages, solitary tumor-forming-type lesions and large tumor cells showed better prognostic factors than other factors, respectively.
  • Self-administered alcohol enema causing chemical proctocolitis. [Journal Article]
    Open Access Emerg Med 2019; 11:129-132Seki T, Fukushima H
  • CONCLUSIONS: Reports on alcohol-induced chemical proctocolitis are rare. None of the reported cases involved perforation or required surgery, and all were resolved with conservative therapy, as observed in the study patient.
  • StatPearls: Lymphogranuloma Venereum Proctocolitis [BOOK]
    StatPearls Publishing: Treasure Island (FL) Sheinman Marc D. MD Swedish Covenant Hospital Vinod Jeevan J BOOK
  • In August 2018, the Centers for Disease Control and Prevention (CDC) presented data at the National STD Prevention Conference that showed sexually transmitted infections (STIs) continue to rise at alarming rates. There were nearly 2.3 million cases of chlamydia, gonorrhea, and syphilis diagnosed in the USA in 2017, surpassing the previous record set in 2016 by more than 200000 cases, and marking …
  • Pyoderma gangrenosum successfully treated with golimumab: Case report and review of the literature. [Journal Article]
    Dermatol Ther 2019; 32(4):e12928Diotallevi F, Campanati A, … Offidani A
  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis frequently related to chronic inflammatory bowel disease (IBD) often associated with exacerbation of intestinal disease and/or loss of treatment efficacy. However, in patients with comorbidities, such as diabetes, the diagnosis may be a challenge. Here, we report the case of a 68-year-old man with a history of ulcerative rectocolitis (UR…
  • Lymphogranuloma venereum (LGV) proctocolitis mimicking rectal lymphoma. [Case Reports]
    Radiol Case Rep 2018; 13(6):1119-1122Sullivan B, Glaab J, … Leiman DA
  • Lymphogranuloma venereum is a sexually transmitted infection caused by serotypes L1-3 of Chlamydia trachomatis and may present as hemorrhagic proctocolitis. The diagnosis of an active infection is difficult to establish, as confirmatory testing can be unreliable or unavailable. Imaging findings can be nonspecific and mimic malignancy or other chronic infectious and inflammatory disorders. In this…
  • StatPearls: Chlamydia [BOOK]
    StatPearls Publishing: Treasure Island (FL) Mohseni Michael M Mayo Clinic Sung Sharon S Sparrow Hospital Takov Veronica V McLaren Macomb Regional Medical Center BOOK
  • Chlamydia is a sexually transmitted infectious disease caused by the bacterium Chlamydia trachomatis. In the United States, it is the most commonly reported bacterial infection. Globally, it is the most common sexually transmitted diseases. It causes an ocular infection called "trachoma," which is the leading infectious cause of blindness worldwide. In females, infertility and ectopic risks incre…
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