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30,456 results
  • Does oxidative stress contribute to toxicity in acute organophosphorus poisoning? - a systematic review of the evidence. [Journal Article]
    Clin Toxicol (Phila) 2019; :1-16Rambabu L, Megson IL, Eddleston M
  • CONCLUSIONS: Several studies showed evidence of OP insecticide-induced oxidative damage and antioxidant activity, suggesting that endogenous antioxidant defences are triggered in acute OP poisoning. However, the markers of lipid peroxidation used were weak, there was high inter-individual variability between studies in results and quality, and marked variation between the OP insecticides involved. Animal data provide some evidence that antioxidants alleviate adverse effects of acute poisoning, suggesting that oxidative stress may directly cause clinical harm. Acetylcysteine appeared beneficial in animal studies, but this could be mediated via increased synthesis of the endogenous detoxifying agent, glutathione, rather than through a direct antioxidant effect. The two human clinical studies were too small to provide any clear evidence to support the use of acetylcysteine in OP poisoning. Further research into the mechanisms of oxidative stress in acute OP poisoning, combined with large unambiguous clinical trials of antioxidants, are required before they can be used routinely in treatment.
  • Isoflurane increases cell membrane fluidity significantly at clinical concentrations. [Journal Article]
    Biochim Biophys Acta Biomembr 2019; :183140Patel J, Chowdhury EA, … Huang J
  • There is an on-going debate whether anesthetic drugs, such as isoflurane, can cause meaningful structural changes in cell membranes at clinical concentrations. In this study, the effects of isoflurane on lipid membrane fluidity were investigated using fluorescence anisotropy and spectroscopy. In order to get a complete picture, four very different membrane systems (erythrocyte ghosts, a 5-lipid m…
  • ATP effects on response of human erythrocyte membrane to high pressure. [Journal Article]
    Biophys Physicobiol 2019; 16:158-166Yamaguchi T, Fukuzaki S
  • Phosphorylation of membrane proteins in human erythrocytes is mediated by intracellular ATP levels. Such phosphorylation modulates the interactions of the bilayer with the cytoskeleton and affects the membrane stability under high pressure. In erythrocytes with high intracellular ATP levels, the bilayer-cytoskeleton interaction was weakened. Compression of such erythrocytes induced the release of…
  • Erythrocyte Membrane Makeover by Plasmodium falciparum Gametocytes. [Review]
    Front Microbiol 2019; 10:2652Neveu G, Lavazec C
  • Plasmodium falciparum sexual parasites, called gametocytes, are the only parasite stages responsible for transmission from humans to Anopheles mosquitoes. During their maturation, P. falciparum gametocytes remodel the structural and mechanical properties of the membrane of their erythrocyte host. This remodeling is induced by the export of several parasite proteins and a dynamic reorganization of…
  • The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection. [Journal Article]
    Malar J 2019; 18(1):381Koch M, Cegla J, … Baum J
  • CONCLUSIONS: Based on these observations, serum cholesterol does not appear to impact on erythrocyte susceptibility to merozoite entry. Indeed, no relationship between serum cholesterol and cholesterol content of the erythrocyte is apparent. This work, nonetheless, suggests that native polymorphisms which do affect membrane lipid composition would be expected to affect parasite entry. This supports investigation of erythrocyte biophysical properties in endemic settings, which may yet identify naturally protective lipid-related polymorphisms.
  • Heat damage of cytoskeleton in erythrocytes increases membrane roughness and cell rigidity. [Journal Article]
    J Biol Phys 2019Parshina EY, Yusipovich AI, … Maksimov GV
  • The intensity of erythrocyte membrane fluctuations was studied by laser interference microscopy (LIM), which provide information about mechanical properties of the erythrocyte membrane. Atomic force microscopy (AFM) was used to study erythrocyte surface relief; it is related to the cytoskeleton structure of erythrocyte membrane. Intact human erythrocytes and erythrocytes with a destroyed cytoskel…
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