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117,463 results
  • Spicy Immunity: Pain to Gain. [Journal Article]
    Immunity 2019; 51(3):426-428Limjunyawong N, Dong X
  • The skin is densely innervated with nociceptive neurons specialized in detecting noxious and painful stimuli. In a recent issue of Cell, Cohen et al. report that activation of cutaneous nociceptive neurons leads to a nerve-reflex action that is sufficient to provide a danger signal that triggers regional immunity to fight a microbial challenge.
  • Sex differences in fatigability and recovery relative to the intensity-duration relationship. [Journal Article]
    J Physiol 2019Ansdell P, Brownstein CG, … Goodall S
  • CONCLUSIONS: Females demonstrate greater fatigue-resistance than males during contractions at intensities relative to maximum force. However, previous studies haven't accounted for the influence of metabolic thresholds on fatigability. This study is the first to test whether sex differences in fatigability exist when exercise intensity is normalised relative to a metabolic threshold: the critical intensity derived from assessment of the intensity-duration relationship during intermittent, isometric knee extensor contractions. We show that critical intensity in females occured at a higher percentage of maximum force compared to males. Furthermore, females demonstrated greater fatigue resistance at exercise intensities above and below this metabolic threshold. Our data suggests that the sex difference was mediated by lesser deoxygenation of the knee-extensors during exercise. These data highlight the importance of accounting for metabolic thresholds when comparing fatigability between sexes, whilst emphasising the notion that male data is not generalisable to female populations.
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