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424 results
  • Laryngotracheal Microbiota in Adult Laryngotracheal Stenosis. [Journal Article]
    mSphere 2019; 4(3)Hillel AT, Tang SS, … Thibeault SL
  • Laryngotracheal stenosis is an obstructive respiratory disease that leads to voicing difficulties and dyspnea with potential life-threatening consequences. The majority of incidences are due to iatrogenic etiology from endotracheal tube intubation; however, airway scarring also has idiopathic causes. While recent evidence suggests a microbial contribution to mucosal inflammation, the microbiota a…
  • Effects of esophageal acid infusion vs mosapride on distension-induced secondary peristalsis in humans. [Journal Article]
    Kaohsiung J Med Sci 2019; 35(5):310-314Lei WY, Hung JS, … Chen CL
  • Secondary peristalsis contributes to the clearance of the refluxate from the esophagus. Acute administration of 5-hydroxytryptamine 4 (5-HT4) receptors agonist, mosapride or esophageal infusion of hydrochloric acid (HCl) facilitates secondary peristalsis. The aim of this study was to determine whether esophageal acid infusion and administration of mosapride had different effects on secondary peri…
  • Pulmonary aspiration in preschool children with cystic fibrosis. [Letter]
    Respir Res 2018; 19(1):255Clarke D, Gorman I, … Mc Nally P
  • Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels…
  • [The acid pocket - a novel target for the treatment of gastro-esophageal reflux disease]. [Journal Article]
    Z Gastroenterol 2018; 56(10):1276-1282Sauter M, Fox MR
  • Increased acid reflux after meals is a key feature of gastro-esophageal reflux disease (GERD) and is the most important cause for patient symptoms, particularly heartburn and acid regurgitation. Chronic acid exposure also predisposes to associated pathologies including reflux esophagitis, esophageal stricture, Barrett's esophagus, and Barrett's carcinoma (esophageal adenocarcinoma). The severity …
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