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Unbound Medicine.
(refluxate)
439 results
  • Bolus Detection in the Proximal Esophagus Using Pulse-Echo Ultrasound: A Feasibility Study. [Journal Article]
    Otolaryngol Head Neck Surg. 2020 May 05 [Online ahead of print]Wilcox A, Jackson D, … Thomas S
  • Here, the feasibility of using nonimaging pulse-echo ultrasound as a method of noninvasively detecting a bolus in the proximal esophagus was demonstrated. To accomplish this, patient swallows were recorded on a clinical ultrasound device with research interface that allowed for collection of the pulse-echo data. These ultrasound data of the proximal esophagus were processed with a series of signa…
  • RNA Sequencing Reveals Cancer-Associated Changes in Laryngeal Cells Exposed to Non-Acid Pepsin. [Journal Article]
    Laryngoscope. 2020 Mar 23 [Online ahead of print]Samuels TL, Zimmermann MT, … Johnston N
  • CONCLUSIONS: A single, brief exposure to pepsin activated cancer-associated signaling pathways in laryngeal cells in vitro, revealing novel mechanisms by which chronic reflux may contribute to carcinogenesis. The cell line developed herein represents a novel tool in which to investigate pepsin-dysregulated pathways identified by RNA sequencing and disparities of tumor proneness of laryngeal subsites.
  • Mechanism and Pathophysiology of Gastroesophageal Reflux Disease. [Review]
    Gastrointest Endosc Clin N Am. 2020 Apr; 30(2):209-226.Zachariah RA, Goo T, Lee RH
  • Gastroesophageal reflux (GER) describes a process in which gastric contents travel retrograde into the esophagus. GER can be either a physiologic phenomenon that occurs in asymptomatic individuals or can potentially cause symptoms. When the latter occurs, this represents GER disease (GERD). The process by which GER transforms into GERD begins at the esophagogastric junction. Impaired clearance of…
  • Predictors of reflux aspiration and laryngo-pharyngeal reflux. [Journal Article]
    Esophagus. 2020 Feb 21 [Online ahead of print]Khoma O, Burton L, … Falk GL
  • CONCLUSIONS: Severe esophageal dysmotility correlates with LPR symptoms and reflux aspiration in LPR and GERD. Abnormal proximal acid score on 24-h pH monitoring associated with pulmonary aspiration in reflux patients. Pharyngeal contamination on scintigraphy was the strongest predictor of pulmonary aspiration.
  • StatPearls: Esophageal pH Monitoring [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Butt Ifrah I Aventura Hospital and Medical Center Kasmin Franklin F Mount Sinai School of Medicine BOOK
  • Gastroesophageal reflux disease (GERD) is a common disorder of the gastrointestinal tract that involves the movement of stomach contents into the esophagus or mouth, causing discomfort or complications.[1] Population-based studies have identified GERD as one of the most common upper gastrointestinal (GI) tract disorders, with a prevalence of about 20% in the United States.[2] Patients may present…
  • Minor esophageal functional disorders: are they relevant? [Review]
    Curr Treat Options Gastroenterol. 2020 Jan 17 [Online ahead of print]Balko RA, Codipilly DC, Ravi K
  • High resolution esophageal manometry (HRM) has expanded understanding of esophageal motor function. The Chicago Classification scheme has allowed systematic categorization of the myriad of manometric parameters identified during HRM. Multichannel intraluminal impedance pH has enhanced ambulatory reflux monitoring through complete assessment of esophageal content transit. However, the clinical imp…
  • Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives. [Review]
    J Neurogastroenterol Motil. 2019 10 30; 25(4):499-507.Lin S, Li H, Fang X
  • Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophagea…
  • Laryngotracheal Microbiota in Adult Laryngotracheal Stenosis. [Journal Article]
    mSphere. 2019 05 01; 4(3)Hillel AT, Tang SS, … Thibeault SL
  • Laryngotracheal stenosis is an obstructive respiratory disease that leads to voicing difficulties and dyspnea with potential life-threatening consequences. The majority of incidences are due to iatrogenic etiology from endotracheal tube intubation; however, airway scarring also has idiopathic causes. While recent evidence suggests a microbial contribution to mucosal inflammation, the microbiota a…
  • Effects of esophageal acid infusion vs mosapride on distension-induced secondary peristalsis in humans. [Journal Article]
    Kaohsiung J Med Sci. 2019 May; 35(5):310-314.Lei WY, Hung JS, … Chen CL
  • Secondary peristalsis contributes to the clearance of the refluxate from the esophagus. Acute administration of 5-hydroxytryptamine 4 (5-HT4) receptors agonist, mosapride or esophageal infusion of hydrochloric acid (HCl) facilitates secondary peristalsis. The aim of this study was to determine whether esophageal acid infusion and administration of mosapride had different effects on secondary peri…
  • Pulmonary aspiration in preschool children with cystic fibrosis. [Letter]
    Respir Res. 2018 Dec 17; 19(1):255.Clarke D, Gorman I, … Mc Nally P
  • Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels…
  • [The acid pocket - a novel target for the treatment of gastro-esophageal reflux disease]. [Journal Article]
    Z Gastroenterol. 2018 Oct; 56(10):1276-1282.Sauter M, Fox MR
  • Increased acid reflux after meals is a key feature of gastro-esophageal reflux disease (GERD) and is the most important cause for patient symptoms, particularly heartburn and acid regurgitation. Chronic acid exposure also predisposes to associated pathologies including reflux esophagitis, esophageal stricture, Barrett's esophagus, and Barrett's carcinoma (esophageal adenocarcinoma). The severity …
  • Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration. [Review]
    Ann N Y Acad Sci. 2018 12; 1434(1):282-289.Johnston N, Dettmar PW, … Bock JM
  • Extra-esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but realization of the role of nonacid reflux has resulted in research investigating the use of pepsin as a biomarker for gastric reflux and aspiration. Pepsin analysis can complement the use of questionnaires and office-based diagnosis and lessen the …
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