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5,033 results
  • Impact of intravenous phenylephrine bolus administration on the nociceptive level index (NOL). [Journal Article]
    J Clin Monit Comput 2019Raft J, Coulombe MA, … Richebe P
  • Recently, the nociceptive level index (NOL) was shown to more specifically and sensitively detect noxious stimuli during anesthesia, in comparison to previous methods that relied on such parameters as heart rate (HR) and mean blood pressure (MAP). An ongoing study (NCT#03410485) evaluates the intraoperative combination of both NOL and bispectral (BIS) indices to improve quality of recovery after …
  • Remifentanil for abdominal surgery is associated unexpectedly unfavorable outcomes. [Journal Article]
    Pain 2019Niedermayer S, Heyn J, … Luchting B
  • Insufficient perioperative pain treatment is known as a highly predictive risk factor for the development of chronic postoperative pain. Remifentanil is an ultrashort-acting opioid that provides quick and efficient analgesia but is associated with the induction of opioid-induced hyperalgesia. Despite these well-known characteristics, this substance is being increasingly used in anesthesia and in …
  • TRPV1 and spinal astrocyte activation contribute to remifentanil-induced hyperalgesia in rats. [Journal Article]
    Neuroreport 2019; 30(16):1095-1101Hong HK, Ma Y, Xie H
  • Remifentanil is an ultra-short-acting µ-opioid receptor agonist, which is widely used in general anesthesia. However, comparing with other opioids, remifentanil often induces hyperalgesia. Accumulating evidence suggests that the transient receptor potential (TRP) channels and glial cells activation were involved in the development of neuropathic pain and hyperalgesia. However, whether the TRP cha…
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