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(renin)
63,151 results
  • β-blocker therapy for infantile haemangioma. [Journal Article]
    Expert Rev Clin Pharmacol. 2020 Jul 14 [Online ahead of print]Koh SP, Leadbitter P, … Tan ST
  • 15% of proliferating infantile haemangioma (IH) require intervention because of the threat to function or life, ulceration or tissue distortion. Propranolol is the mainstay treatment for problematic proliferating IH. Other β-blockers and angiotensin-converting enzyme (ACE) inhibitors have been explored as alternative treatments.
  • Autophagy in diabetic nephropathy: a review. [Review]
    Int Urol Nephrol. 2020 Jul 13 [Online ahead of print]Koch EAT, Nakhoul R, … Nakhoul N
  • Diabetes mellitus (DM) is the leading cause of end stage renal disease. 40% of the patients worldwide will require replacement therapy after 20 years of DM worldwide. Early-stage diabetic nephropathy is characterized by hyperfiltration related to hypeglycemia-induced afferent artery vasodilatation with micro-and macroalbuminuria. Later on, proteinuria with arterial hypertension may appear, culmin…
  • Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. [Review]
    Crit Care. 2020 Jul 13; 24(1):422.Ni W, Yang X, … Gao Z
  • An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organs. We have reviewed previously published studies on SARS and recent studies on S…
  • COVID-19, Renin-Angiotensin System and Endothelial Dysfunction. [Review]
    Cells. 2020 Jul 09; 9(7)Amraei R, Rahimi N
  • The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused by SARS-CoV-2 virus, has posed a serious threat to global public health and caused worldwide social and economic breakdown. Angiotensin-converting enzyme 2 (ACE2) is expressed in human vascular endothelium, respiratory epithelium, and other cell types, and is thought to be a primary mechanism of SARS-CoV-2 entr…
  • The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19. [Review]
    Pharmacol Res Perspect. 2020 Aug; 8(4):e00623.Braga CL, Silva-Aguiar RP, … Silva PL
  • Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics whi…
  • Restricted Water Intake Adversely Affects Rat Vocal Fold Biology. [Journal Article]
    Laryngoscope. 2020 Jul 13 [Online ahead of print]Duan C, do Nascimento NC, … Sivasankar MP
  • CONCLUSIONS: Reduced daily water intake for just 5 days impairs vocal fold biology by disrupting inflammatory cytokine release, reducing plasma membrane integrity, and disrupting the hyaluronan network. This is the first study investigating the dehydrating effects of restricted water intake on vocal fold tissue in an in vivo model.
  • Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions. [Case Reports]
    Electrolyte Blood Press. 2020 Jun; 18(1):10-15.Choi JY, Cho SG, … Kim GH
  • Voriconazole, a triazole antifungal agent used to treat serious fungal infections, has a pharmacokinetic characteristic of undergoing hepatic metabolism by the cytochrome P450 system. Few cases of hyperkalemia have been reported, which presented only when the serum voriconazole level was exceptionally elevated by drug-drug interactions. Additionally, azole antifungals may interfere with the biosy…
  • Pharmacotherapy Considerations in CKD Patients With COVID-19, A Narrative Review. [Journal Article]
    Iran J Kidney Dis. 2020 07; 14(4):247-255.Dashti-Khavidaki S, Khalili H, Nourian A
  • Treatment of coronavirus disease 2019 (COVID-19) among patients with CKD requires special pharmacotherapy considerations that are reviewed here. Literature review was done for several pharmacotherapy aspects in CKD patients including selection and modification of COVID-19 treatment, drug interactions, nephrotoxicity of drugs that are used for treatment of COVID-19 and potential risks/benefits of …
  • Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow's triad. [Review]
    Clin Rheumatol. 2020 Jul 11 [Online ahead of print]Ahmed S, Zimba O, Gasparyan AY
  • The pathogenesis of Coronavirus disease 2019 (COVID-19) is gradually being comprehended. A high number of thrombotic episodes are reported, along with the mortality benefits of heparin. COVID-19 can be viewed as a prothrombotic disease. We overviewed the available evidence to explore this possibility. We identified various histopathology reports and clinical case series reporting thromboses in CO…
  • Good or bad: Application of RAAS inhibitors in COVID-19 patients with cardiovascular comorbidities. [Review]
    Pharmacol Ther. 2020 Jul 09 [Online ahead of print]Wang JJ, Edin ML, … Chen C
  • The coronavirus disease 2019 (COVID-19) pandemic is caused by a newly emerged coronavirus (CoV) called Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). COVID-19 patients with cardiovascular disease (CVD) comorbidities have significantly increased morbidity and mortality. The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor type 1 blockers (ARBs) impro…
  • Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era. [Review]
    Am J Med. 2020 Jul 09 [Online ahead of print]Massoomi MR, Anderson RD, … Pepine CJ
  • It is clear that existing cardiovascular disease is a major risk factor for COVID-19 and related adverse outcomes. In addition to acute respiratory syndrome, a large cohort also develop myocardial and/or vascular dysfunction, in part from inflammation and renin angiotensin system activation with increased sympathetic outflow, cardiac arrhythmias, ischemia, heart failure, and thromboembolic compli…
  • Endocrine significance of SARS-CoV-2's reliance on ACE2. [Journal Article]
    Endocrinology. 2020 Jul 11 [Online ahead of print]Lazartigues E, Qadir MMF, Mauvais-Jarvis F
  • The current COVID-19 pandemic is the most disruptive event in the last 50 years with global impact on healthcare and world economies. It is caused by SARS-CoV-2, a coronavirus that uses angiotensin converting enzyme 2 (ACE2), as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review, summarizes the main findings regarding…
  • Uric acid and risk of diabetic kidney disease. [Review]
    J Nephrol. 2020 Jul 10 [Online ahead of print]Mauer M, Doria A
  • Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the Western world. Better control of glycemia and blood pressure, including renin-angiotensin system blockade (RASB), appear to have slowed DKD progression rate but have been unable to substantially decrease the annual incidence of new cases of DKD related ESKD. Thus, new treatment targets are needed. Higher …
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