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(renin substrate)
6,466 results
  • Absolute Quantitation of Oxidizable Peptides by Coulometric Mass Spectrometry. [Journal Article]
    J Am Soc Mass Spectrom 2019; 30(11):2398-2407Zhao P, Zare RN, Chen H
  • Quantitation methods for peptides using mass spectrometry have advanced rapidly. These methods rely on using standard and/or isotope-labeled peptides, which might be difficult or expensive to synthesize. To tackle this challenge, we present a new approach for absolute quantitation without the use of standards or calibration curves based on coulometry combined with mass spectrometry (MS). In this …
  • The pathogenic AGT c.856+1G>T mutation of a patient with multiple renal cysts and hypertension. [Case Reports]
    Ann Transl Med 2019; 7(22):699Chen W, Li B, … Chen J
  • Angiotensinogen (AGT) is an essential member of the renin-angiotensin system (RAS); this system regulates blood pressure and affects the physiological function of the kidney. Studies found that mutations of the human AGT gene are involved in diseases such as recessive renal tubular dysgenesis (RTD) and essential hypertension (EHT). Here, we report a 29-year-old male Chinese with essential hyperte…
  • Strawberry (Fragaria × ananassa cv. Romina) methanolic extract promotes browning in 3T3-L1 cells. [Journal Article]
    Food Funct 2020Forbes-Hernández TY, Cianciosi D, … Battino M
  • In recent years, the conversion of white adipocytes to brown-like adipocytes by pharmacological and dietary compounds has gained attention as an effective strategy to fight obesity. Strawberry bioactive compounds present several biological activities including antioxidant, anti-inflammatory, anti-cancer, anti-atherosclerotic and antiadipogenic properties. However, to the best of our knowledge, th…
  • Targeting angiotensinogen with RNA-based therapeutics. [Journal Article]
    Curr Opin Nephrol Hypertens 2019Ren L, Colafella KMM, … Danser AHJ
  • CONCLUSIONS: Targeting angiotensinogen with RNA-based therapeutics is a promising new tool to treat hypertension and diseases beyond. Their long-lasting effects are particularly exciting, and if translated to a clinical application of at most a few administrations per year, may help to eliminate nonadherence.
  • Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra. [Journal Article]
    Brain Behav Immun 2019Rodriguez-Perez AI, Garrido-Gil P, … Labandeira-Garcia JL
  • Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the above-mentioned AT1-related effects in the aged brain, particularly substantia nigra, was investigated in this study. In the nigra, we observed a progressive decrease in AT2 mRNA expression with aging, and AT2 deletion led to …
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