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(renin substrate)
6,425 results
  • IgE-Mediated Systemic Anaphylaxis And Its Association With Gene Polymorphisms Of ACE, Angiotensinogen And Chymase. [Journal Article]
    J Asthma Allergy 2019; 12:343-361Varney VA, Nicholas A, … Sumar N
  • CONCLUSIONS: Our gene polymorphisms show lower RAS activity for anaphylaxis especially AACVS. Animal models of anaphylaxis are focused on endothelial nitric oxide (eNO) which is shown to be the mediator of fatal shock and prevented by eNO-blockade. The interaction of AII and eNO controls the microcirculation in man. High serum AII levels reduce eNO activity, so higher RAS-activity could protect against shock. Our data shows low RAS activity in anaphylaxis especially AACVS, suggesting the influence of these genes on shock are via AII levels and its effects on eNO.
  • Angiotensin-(1-12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen. [Journal Article]
    Int J Cardiol 2019Reyes S, Cheng CP, … Ferrario CM
  • CONCLUSIONS: Our data demonstrate the existence in cardiomyocytes of a calcium channel modulatory activity responsive to Ang II generated by the Ang-(1-12)/chymase axis that signals via intracellular receptors. Chronically elevated Ang II in TGR(hAGT)L1623 hearts leading to increased intracellular calcium through ICa-L suggests that activation of this Ang-(1-12)/chymase-governed cardiac intracrine RAS may contribute to the pathological phenotypes observed in the humanized model of chronic hypertension and cardiac hypertrophy.
  • Control of the retinal local RAS by the RPE: An interface to systemic RAS activity. [Review]
    Exp Eye Res 2019; :107838Reichhart N, Figura A, … Strauβ O
  • As many other organs, the retina has a local renin-angiotensin-system (RAS). All main elements of the RAS are active in the retina: renin, angiotensinogen, angiotensin-converting enzymes. The functional role of the intraretinal RAS is not fully understood. So far, histological and functional analysis point to a regulation of ganglion cell activity and maybe also of bipolar cell activity, but it i…
  • Genetics and ESKD Disparities in African Americans. [Journal Article]
    Am J Kidney Dis 2019Umeukeje EM, Young BA
  • African Americans have a 2- to 4-fold greater incidence of end-stage kidney disease (ESKD) than whites, which has long raised the possibility of a genetic cause for this disparity. Recent advances in genetic studies have shown a causal association of polymorphisms at the apolipoprotein L1 gene (APOL1) with the markedly increased risk for the nondiabetic component of the overall disparity in ESKD …
  • Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus. [Journal Article]
    Physiol Rep 2019; 7(19):e14242Ba Aqeel S, Ye M, … Diabetes Control, Complications Trial (DCCT)/Epidemiology of Diabetes Interventions, Complications (EDIC) Study
  • We examined if urinary angiotensinogen (uAOG), a marker of intrarenal renin-angiotensin system activity, antedates stage 3 chronic kidney disease (CKD) using samples from participants in the Diabetes Control and Complications Trial (DCCT) and later in the Epidemiology of Diabetes Intervention and Complications (EDIC) trial. In a nested case-control design, cases were matched at the outcome visit …
  • Angiotensinogen in Hepatocytes Contributes to Western Diet-induced Liver Steatosis. [Journal Article]
    J Lipid Res 2019Tao XR, Rong JB, … Wang JA
  • Non-alcoholic fatty liver disease (NAFLD) is considered as a liver manifestation of metabolic disorders. Previous studies indicate that renin-angiotensin system (RAS) plays a complex role in NAFLD. As the only precursor of RAS, decreased angiotensinogen (AGT) profoundly impacts RAS bioactivity. Here we investigated the role of hepatocyte-derived AGT in liver steatosis. AGT floxed mice (hepAGT+/+)…
  • Vitamin D Receptor Deficiency Does Not Affect Blood Pressure and Heart Function. [Journal Article]
    Front Physiol 2019; 10:1118Grundmann SM, Schutkowski A, … Stangl GI
  • Vitamin D is thought to play a role in blood pressure regulation, which in turn can influence cardiovascular risk. Several meta-analyses of cohort studies found low serum levels of 25-hydroxyvitamin D to be associated with increased blood pressure or increased cardiovascular morbidity and mortality in the general population. Active vitamin D mediates its function via the vitamin D receptor (Vdr),…
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