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807 results
  • Precision medicine in diabetes. [Journal Article]
    J Pak Med Assoc 2019; 69(9):1394-1395Kalra S, Chaudhary S
  • This review presents the dynamic and fast growing concept of precision medicine in a simple and succinct manner. It describes the potential of precision medicine in diabetes praxis, under three headings: diagnosis of type of diabetes, choice of pharmacotherapy for glucose lowering, and management of complications of diabetes. This review should make the scope of precision medicine easy to underst…
  • Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM. [Journal Article]
    Elife 2019; 8Martin GM, Sung MW, … Shyng SL
  • ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent cell surface expression and cause congenital hyperinsulinism. Structurally diverse KATP inhibitors are …
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