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18,236 results
  • Reserpine attenuates biofilm formation and virulence of Staphylococcus aureus. [Journal Article]
    Microb Pathog 2019; :103790Parai D, Banerjee M, … Mukherjee SK
  • This study investigated the effects of reserpine, the main bioactive compound of Rauwolfia serpentina, on biofilm formation and biofilm-associated virulence factors production in a Gram-positive pathogen, Staphylococcus aureus. Crystal violet assay, MTT assay, Congo red binding, CLSM studies were performed to assess the antibiofilm activity. Molecular docking was performed to explain the possible…
  • Venlafaxine plus melatonin ameliorate reserpine-induced depression-like behavior in zebrafish. [Journal Article]
    Neurotoxicol Teratol 2019; 76:106835Tang YQ, Li ZR, … Feng XZ
  • Venlafaxine (VEN) is one of the first clinical drugs for the treatment of depression. Long-term use may cause a potentially life-threatening serotonin syndrome. Melatonin (MT) could ameliorate depression behavior. Therefore, the aim of this study was to investigate the antidepressant effects of venlafaxine in combination with melatonin on zebrafish. Reserpine was used to induce depression-like be…
  • Phagocytic elimination of synapses by microglia during sleep. [Journal Article]
    Glia 2019Choudhury ME, Miyanishi K, … Tanaka J
  • Synaptic strength reduces during sleep, but the underlying mechanisms of this process are unclear. This study showed reduction of synaptic proteins in rat prefrontal cortex (PFC) at AM7 or Zeitgeber Time (ZT0), when the light phase or sleeping period for rats started. At this time point, microglia were weakly activated, displaying larger and more granular somata with increased CD11b expression co…
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