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82,109 results
  • StatPearls: Thrombocytopenia Pregnancy [BOOK]
    StatPearls Publishing: Treasure Island (FL) Mangla Ankit A Case Western Reserve University Hamad Hussein H University Hospitals/Case Western Univ BOOK
  • Thrombocytopenia, defined as a platelet count of under 150 x 10^9/L, is the second most common hematological abnormality in pregnancy.[1][2] An International working group adopted a lower threshold of platelets, 100 x 10^9/L to define immune thrombocytopenia, a count observed in less than 1% of all pregnancies.[1][3][2] Thrombocytopenia in pregnancy occurs either due to obstetric conditions (like…
  • StatPearls: Vasomotor Rhinitis [BOOK]
    StatPearls Publishing: Treasure Island (FL) Leader Preston P University of Kentucky Geiger Zachary Z Western Reserve Hospital BOOK
  • Nonallergic rhinitis (NAR) describes a syndrome of chronic symptoms of nasal congestion and rhinorrhea, unrelated to a specific allergen. Nonallergic rhinitis can subdivide into numerous different subtypes with vasomotor rhinitis (VMR) being the most common type. Vasomotor rhinitis is a term often used to describe rhinitis symptoms associated with nonallergic, noninfectious triggers with no clear…
  • StatPearls: Intellectual Disability [BOOK]
    StatPearls Publishing: Treasure Island (FL) Lee Keun K Aventura Hospital and Medical Center Cascella Marco M Istituto Nazionale Tumori - IRCCS - Fondazione Pascale, Via Mariano Semmola 80100, Napoli. Italy Marwaha Raman R Case Western Reserve Un/MetroHealth MC BOOK
  • Individuals with an intellectual disability have neurodevelopmental deficits characterized by limitations in intellectual functioning and adaptive behavior. These disabilities originate and manifest before the age of 18 and can be associated with a considerable number of related and co-occurring problems including mental health (e.g., depression, and anxiety), neurodevelopmental (e.g., autism spe…
  • An improved platform for functional assessment of large protein libraries in mammalian cells. [Journal Article]
    Nucleic Acids Res 2019Matreyek KA, Stephany JJ, … Fowler DM
  • Multiplex genetic assays can simultaneously test thousands of genetic variants for a property of interest. However, limitations of existing multiplex assay methods in cultured mammalian cells hinder the breadth, speed and scale of these experiments. Here, we describe a series of improvements that greatly enhance the capabilities of a Bxb1 recombinase-based landing pad system for conducting differ…
  • MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria. [Journal Article]
    J Immunol 2019Suliman S, Murphy M, … Scriba TJ
  • Tuberculosis (TB) is the leading cause of mortality from a single infectious agent, Mycobacterium tuberculosis Relevant immune targets of the partially efficacious TB vaccine bacille Calmette-Guérin (BCG) remain poorly defined. Mucosal-associated invariant T (MAIT) cells are MHC-related protein 1 (MR1)-restricted T cells, which are reactive against M. tuberculosis, and underexplored as potential …
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