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45,425 results
  • In silico screening of anti-inflammatory compounds from Lichen by targeting cyclooxygenase-2. [Journal Article]
    J Biomol Struct Dyn 2019; :1-19Joshi T, Sharma P, … Chandra S
  • Non-steroidal anti-inflammatory drugs (NSAID) targeting cyclooxygenase-2 are clinically effective. However, they lack anti-thrombotic activity resulting in incidences of adverse effects like myocardial infarction, gastrointestinal and abdominal discomfort which necessitate for discovering new drug candidates with improved therapeutic effects and tolerability. Various recent researches have sugges…
  • Structural insights into coronavirus entry. [Journal Article]
    Adv Virus Res 2019; 105:93-116Tortorici MA, Veesler D
  • Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome cor…
  • Lineage-specific rapid diagnostic tests can resolve Trypanosoma cruzi TcII/V/VI ecological and epidemiological associations in the Argentine Chaco. [Journal Article]
    Parasit Vectors 2019; 12(1):424Murphy N, Macchiaverna NP, … Miles MA
  • CONCLUSIONS: We show here that Chagas Sero K-SeT RDT can replace ELISA for TSSApep-II/V/VI serology of humans and dogs; for humans there were statistically significant associations between a positive Chagas Sero K-SeT RDT and being resident in Area IV, and for dogs association with Qom household or with being born before the mass spraying campaign; we also show that with cats the TcII/V/VI epitope can be detected by ELISA. We assessed the lineage distribution in an unprecedented 83% of the human T. cruzi-seropositive population. These results form the basis for more detailed studies, enabling rapid in-the-field surveillance of the distribution and clustering of these lineages among humans and mammalian reservoirs of T. cruzi infection.
  • Neurocognitive Complications of Pediatric HIV Infections. [Journal Article]
    Curr Top Behav Neurosci 2019Benki-Nugent S, Boivin MJ
  • The prevalence of cognitive impairment or learning difficulties in HIV-infected children is high despite access to antiretroviral treatment (ART). Several biological mechanisms, including latent HIV reservoir persistence in the brain, local inflammation within the central nervous system (CNS), disruption of neuronal function and integrity, and ongoing infiltration of activated HIV target cells to…
  • Impact of bloom events on dissolved organic matter fluorophore signatures in Ohio waters. [Journal Article]
    Sci Total Environ 2019; 699:134003Hipsher C, Barker J, MacKay A
  • Due to the increase in severe cyanobacterial blooms in drinking water sources and recreational waters across the globe, inexpensive and reliable methods of detecting oncoming blooms are needed. Cyanobacterial blooms can contribute substantially to the bulk chromophoric dissolved organic matter pool. Thus, the fluorescence signature of organic matter derived from these blooms may be an indicator o…
  • Shedding light on the presymbiontic phase of C. arietinum. [Journal Article]
    Plant Physiol Biochem 2019; 143:224-231Farci D, Sanna C, … Piano D
  • A complex network of symbiotic events between plants and bacteria allows the biosphere to exploit the atmospheric reservoir of molecular nitrogen. In seeds, a series of presymbiotic steps are already identified during imbibition, while interactions between the host and its symbiont begin in the early stages of germination. In the present study, a detailed analysis of the substances' complex deliv…
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