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689 results
  • Resolution metabolomes activated by hypoxic environment. [Journal Article]
    Sci Adv 2019; 5(10):eaax4895Norris PC, Libreros S, Serhan CN
  • Targeting hypoxia-sensitive pathways in immune cells is of interest in treating diseases. Here, we demonstrate that physiologic hypoxia (1% O2), as encountered in bone marrow and spleen, accelerates human M2 macrophage efferocytosis of apoptotic-neutrophils and senescent erythrocytes via lipolysis-dependent biosynthesis of specialized pro-resolving mediators (SPMs), i.e. resolvins, protectins, ma…
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