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2,350,858 results
  • Functional Deimmunization of Interferon Beta-1b by Identifying and Silencing Human T Cells Epitopes. [Journal Article]
    Iran J Allergy Asthma Immunol 2019; 18(4):427-440Moradi Hasan-Abad A, Adabi E, … Kardar GA
  • Interferonbeta-1b (IFNβ-1b) developed as therapeutic protein for the treatment of multiple sclerosis (MS). Studies have been shown that Long-term usage of this protein can lead to the development of anti-drug antibodies (ADAs) and this phenomenon cause total loss or reduced efficacy of IFNβ-1b. The aim of this study was to predict and silence IFNβ-1b T-cells epitopes by in silico methods and gene…
  • In Silico Structural Prediction and Production of a Chimeric Recombinant Dickkopf-1 (DKK-1) Antigen. [Journal Article]
    Iran J Allergy Asthma Immunol 2019; 18(3):269-280Malaei F, Rasaee MJ, … Rahbarizadeh F
  • Dickkopf (DKK) family of proteins are known as antagonists for the Wnt-β-catenin signaling pathway. It is suggested that the Dickkopf-1 (DKK-1) has a role in several diseases such as hepatocellular carcinomas, hepatoblastomas, Wilms' tumors, lung cancer and Myeloma bone disease. The aim of the present study was to produce a chimeric-recombinant DKK-1 protein in order to induce immune response aga…
  • Clinical Flow-Cytometric Testing in Chronic Lymphocytic Leukemia. [Journal Article]
    Methods Mol Biol 2019; 2032:311-321Salem DA, Stetler-Stevenson M
  • Flow-cytometric demonstration of the typical chronic lymphocytic leukemia (CLL) immunophenotype is vital for diagnosis. CLL has a characteristic immunophenotype, expressing CD5, CD19, dim CD20, dim CD22, CD23, bright CD43, dim CD45, dim to negative CD79b, dim CD81, CD200, and dim monoclonal surface immunoglobulin. This characteristic immunophenotype allows a definitive diagnosis and the ruling ou…
  • Rare Event Phenotyping and Molecular Characterization: Circulating Tumor Cells. [Journal Article]
    Methods Mol Biol 2019; 2032:213-226Sen M, Wang L, … Carpenter EL
  • Noninvasive isolation of circulating tumor cells (CTCs) from patient blood samples allows for interrogation of valuable molecular and phenotypic information useful for disease diagnosis and monitoring response to therapy. However, CTCs are extremely rare relative to red and white blood cells (R/WBC), thus making CTC isolation from unmanipulated whole blood very time-consuming. Moreover, single CT…
  • Multiparametric Flow Cytometry Analysis of Naïve, Memory, and Effector T Cells. [Journal Article]
    Methods Mol Biol 2019; 2032:129-140Saxena A, Dagur PK, Biancotto A
  • Polychromatic flow cytometry enables the detection and characterization of markers which are helpful in defining phenotype of various cell subsets. Here we describe flow cytometry-based method to characterize phenotype of naïve, memory, and effector T cells. Being able to differentiate these cells is crucial in understanding immune response, and immune profiling. Naïve T cells enable the body to …
  • Strategies and Techniques for NK Cell Phenotyping. [Journal Article]
    Methods Mol Biol 2019; 2032:105-114Ziqing C, Lundqvist A, Witt K
  • Therapies based on activating the immune system, that is, immunotherapy, are now widely implemented in clinical praxis in patients with advanced cancer. Although cancer immunotherapy can result in long-lasting clinical responses, the majority of patients do not respond or develop resistance. Furthermore, cancer immunotherapy is being increasingly combined with other forms of immunotherapy or conv…
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