- Modified Oblique Keller Capsular Interposition Arthroplasty for Hallux Rigidus. [Journal Article]
- JEJBJS Essent Surg Tech 2012; 2(1):e3
- This paper describes the modified oblique Keller capsular interposition arthroplasty, which may be indicated for patients with late-stage hallux rigidus who wish to retain joint motion.
This paper describes the modified oblique Keller capsular interposition arthroplasty, which may be indicated for patients with late-stage hallux rigidus who wish to retain joint motion.
- Under pressure: force resistance measurements in box mites (Actinotrichida, Oribatida). [Journal Article]
- FZFront Zool 2019; 16:24
- CONCLUSIONS: We showed the feasibility of the force resistance measurement method, and our results were consistent with the hypothesis that Phthiracaroidea compensated its lack of chemical secretions by a heavier mechanical resistance based on a different body form and associated build-up of hemolymph pressure (defensive trade-off).
- Reasons for and time to retraction of genetics articles published between 1970 and 2018. [Journal Article]
- JMJ Med Genet 2019 Jul 12
- CONCLUSIONS: Genetics is a discipline with a high article retraction rate (estimated retraction rate 0.15%). Fabrication/falsification and plagiarism were almost mutually exclusive reasons for article retraction. Retracted MG articles were more frequently subject to investigation than NMG articles. Retracted articles due to fabrication/falsification required 2.0-2.8 times longer to retract than when plagiarism was involved.
- RETRACTION: Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Müller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood. 2011;117(8):2423-2432. [Journal Article]
- BloodBlood 2019 Jul 11
- The Editors of Blood retract the 24 February 2011 paper cited above. Concerns regarding the data underlying Figures 3A, 3B, 3C, 4A, and 5C were brought to the attention of Stanford University. The un…
The Editors of Blood retract the 24 February 2011 paper cited above. Concerns regarding the data underlying Figures 3A, 3B, 3C, 4A, and 5C were brought to the attention of Stanford University. The university investigated the issue, conducting a search for any original sources of these data. The search was unsuccessful; the experiments, data, and figure preparation for these figures were overseen by Holbrook E. Kohrt, who passed away before the university became aware of the concerns. As a result, the data underlying these figures cannot be validated. Holbrook E. Kohrt is deceased and cannot consent to the retraction. Kipp Weiskopf, Ash A. Alizadeh, Josh Brody, Debra Czerwinski, Steven Coutre, Mark P. Chao, Thomas F. Tedder, and Ronald Levy approve the retraction. Roch Houot, Matthew J. Goldstein, Antonia M.S. Müller, Russell Pachynski, and Lieping Chen could not be reached for a response.
- Holmium Laser Enucleation of the Prostate After Failed UroLift: Surgical Considerations for the Management of Non-Absorbable Implants. [Journal Article]
- UUrology 2019 Jul 01
- CONCLUSIONS: HOLEP can be performed safely in the UroLift failure patient population. Careful morcellation techniques can decrease the risk of costly morcellator blade replacement.
- The Clinical Rationale for the Sentry Bioconvertible Inferior Vena Cava Filter for the Prevention of Pulmonary Embolism. [Review]
- IJInt J Vasc Med 2019; 2019:5795148
- The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection against pulmonary embolism (PE) during transient high-risk periods and then to bioconvert after 60 days after im…
The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection against pulmonary embolism (PE) during transient high-risk periods and then to bioconvert after 60 days after implantation. At the time of bioconversion, the device's nitinol arms retract from the filtering position into the caval wall. Subsequently, the stable stent-like nitinol frame is endothelialized. The Sentry bioconvertible IVC filter has been evaluated in a multicenter investigational-device-exemption pivotal trial (NCT01975090) of 129 patients with documented deep vein thrombosis (DVT) or PE, or at temporary risk of developing DVT or PE, and with contraindications to anticoagulation. Successful filter conversion was observed in 95.7% of patients at 6 months (110/115) and 96.4% at 12 months (106/110). Through 12 months, there were no cases of symptomatic PE. The rationale for development of the Sentry bioconvertible device includes the following considerations: (1) the period of highest risk of PE for the vast majority of patients occurs within the first 60 days after an index event, with most of the PEs occurring in the first 30 days; (2) the design of retrievable IVC filters to support their removal after a transitory high-PE-risk period has, in practice, been associated with insecure filter dynamics and time-dependent complications including tilting, fracture, embolization, migration, and IVC perforation; (3) most retrievable IVC filters are placed for temporary protection, but for a variety of reasons they are not removed in any more than half of implanted patients, and when removal is attempted, the procedure is not always successful even with advanced techniques; and (4) analysis of Medicare hospital data suggests that payment for the retrieval procedure does not routinely compensate for expense. The Sentry device is not intended for removal after bioconversion. In initial clinical use, complications have been limited. Long-term results for the Sentry bioconvertible IVC filter are anticipated soon.
- Greater growth stability of trees in marginal habitats suggests a patchy pattern of population loss and retention in response to increased drought at the rear edge. [Letter]
- ELEcol Lett 2019 Jun 27
- Species rear range edges are predicted to retract as climate warms, yet evidence of population persistence is accumulating. Accounting for this disparity is essential to enable prediction and plannin…
Species rear range edges are predicted to retract as climate warms, yet evidence of population persistence is accumulating. Accounting for this disparity is essential to enable prediction and planning for species' range retractions. At the Mediterranean edge of European beech-dominated temperate forest, we tested the hypothesis that individual performance should decline at the limit of the species' ecological tolerance in response to increased drought. We sampled 40 populations in a crossed factor design of geographical and ecological marginality and assessed tree growth resilience and decline in response to recent drought. Drought impacts occurred across the rear edge, but tree growth stability was unexpectedly high in geographically isolated marginal habitat and lower than anticipated in the species' continuous range and better-quality habitat. Our findings demonstrate that, at the rear edge, range shifts will be highly uneven and characterised by reduction in population density with local population retention rather than abrupt range retractions.
- Retracted: Expression of Lymphocyte-Activation Gene 3 (LAG-3) Immune Checkpoint Receptor Identifies a Tumor-Reactive T Cell Population in the Peripheral Blood of Patients with Colorectal Cancer. [Retraction of Publication]
- MSMed Sci Monit 2019 06 13; 25:4400
- This article is retracted due to authors' claims in regards to errors in data and statistical analyses. Authors' message: We greatly regret to inform you that we just discovered some fatal errors in …
This article is retracted due to authors' claims in regards to errors in data and statistical analyses. Authors' message: We greatly regret to inform you that we just discovered some fatal errors in the statistical analysis, in which we mistakenly used the cultured cells TCR sequencing data as the results of CD8+ LAG3+ and CD8 LAG3-T cells. Therefore, the current results and data have serious defects and do not accurately represent the sorted cells. On behalf of all the contributing authors of the manuscript, we have decided to immediately retract the manuscript titled "LAG-3 receptor identifies a higher tumor-reactive cell population in the peripheral blood of colorectal cancer patients" to avoid further problems.
- Elongated Cells Drive Morphogenesis in a Surface-Wrapped Finite-Element Model of Germband Retraction. [Journal Article]
- BJBiophys J 2019 Jul 09; 117(1):157-169
- During Drosophila embryogenesis, the germband first extends to curl around the posterior end of the embryo and then retracts back; however, retraction is not simply the reversal of extension. At a ti…
During Drosophila embryogenesis, the germband first extends to curl around the posterior end of the embryo and then retracts back; however, retraction is not simply the reversal of extension. At a tissue level, extension is coincident with ventral furrow formation, and at a cellular level, extension occurs via convergent cell neighbor exchanges in the germband, whereas retraction involves only changes in cell shape. To understand how cell shapes, tissue organization, and cellular forces drive germband retraction, we investigate this process using a whole-embryo, surface-wrapped cellular finite-element model. This model represents two key epithelial tissues-amnioserosa and germband-as adjacent sheets of two-dimensional cellular finite elements that are wrapped around an ellipsoidal three-dimensional approximation of an embryo. The model reproduces the detailed kinematics of in vivo retraction by fitting just one free model parameter, the tension along germband cell interfaces; all other cellular forces are constrained to follow ratios inferred from experimental observations. With no additional parameter adjustments, the model also reproduces quantitative assessments of mechanical stress using laser dissection and failures of retraction when amnioserosa cells are removed via mutations or microsurgery. Surprisingly, retraction in the model is robust to changes in cellular force values but is critically dependent on starting from a configuration with highly elongated amnioserosa cells. Their extreme cellular elongation is established during the prior process of germband extension and is then used to drive retraction. The amnioserosa is the one tissue whose cellular morphogenesis is reversed from germband extension to retraction, and this reversal coordinates the forces needed to retract the germband back to its pre-extension position and shape. In this case, cellular force strengths are less important than the carefully established cell shapes that direct them. VIDEO ABSTRACT .
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- Evaluation of urinary 8-hydroxy-2-deoxyguanosine level in experimental Alzheimer's disease: Impact of carvacrol nanoparticles. [Journal Article]
- MBMol Biol Rep 2019 Jun 17
- The present study aimed to compare the effect of carvacrol essential oil and carvacrol nanoemulsion against experimental Alzheimer's (AD). Forty male albino rats were used and divided into four group…
The present study aimed to compare the effect of carvacrol essential oil and carvacrol nanoemulsion against experimental Alzheimer's (AD). Forty male albino rats were used and divided into four groups as follow: control, AlCl3 induced AD, carvacrol oil treated and carvacrol nanoemulsion treated groups. Brain nor-epinephrine, serotonin and dopamine were analyzed by high performance liquid chromatography (HPLC). Levels of brain Thiobarbituric acid-reactive substances (TBARS), Superoxide dismutase (SOD), reduced glutathione (GSH), cholinesterase, and advanced oxidation protein product (AOPP) were evaluated. Urinary 8-hydroxyguanosine (8-OHdG) level was evaluated by HPLC. Brain Cyclooxygenase 1 and 2 (COX 1and 2) were analyzed by immunohistochemistry. AD induced by AlCl3 in rats was depicted by the significant increase in the neurotransmitters levels which is accompanied with high degree of oxidative stress that was revealed in the elevated level of urinary 8-OHdG along with significant elevation in AOPP, TBARS, and cholinesterase levels and a significant decrease in SOD and GSH; these results are confirmed by immunohistochemistry analysis of COX 1 and 2. On the other hand, the treatment with carvacrol oil and carvacrol nanoemulsion were capable of mitigate effects mediated by AlCl3 administration in treated rats. While the treatment with both approached succeeded to retract the negative impact of AlCl3; but the effect of carvacrol nanoemulsion was more notable than the essential oil. Carvacrol oil and carvacrol nanoemulsion were eminent to overturn AlCl3 induced brain AD which could be imputed to antioxidant and anti-inflammatory capabilities of carvacrol to alter oxidative stress effect. In extension; carvacrol nanoemulsion were evident to give more effective and efficient way in carvacrol delivery to pass through blood brain barriers and ameliorate brain changes.