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3,075 results
  • An evaluation of enasidenib for the treatment of acute myeloid leukemia. [Journal Article]
    Expert Opin Pharmacother 2019; :1-8Del Principe MI, Paterno G, … Venditti A
  • Introduction: Despite recent progress, the prognosis of acute myeloid leukemia remains poor, mainly in older and in relapsed/refractory patients. Recently, a large number of novel agents have been developed thanks to a better understanding of its pathogenesis. Among these, the potent inhibitor of the isocitrate dehydrogenase-2 (IDH2) mutant protein, enasidenib (formerly AG-221), has demonstrated …
  • Finding of Agr Phase Variants in Staphylococcus aureus. [Journal Article]
    MBio 2019; 10(4)Gor V, Takemura AJ, … Morikawa K
  • Staphylococcus aureus is an important human pathogen whose success is largely attributed to its vast arsenal of virulence factors that facilitate its invasion into, and survival within, the human host. The expression of these virulence factors is controlled by the quorum sensing accessory gene regulator (Agr) system. However, a large proportion of clinical S. aureus isolates are consistently foun…
  • AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice. [Journal Article]
    Mol Ther 2019; 27(9):1568-1585Nance ME, Shi R, … Duan D
  • CRISPR editing of muscle stem cells (MuSCs) with adeno-associated virus serotype-9 (AAV9) holds promise for sustained gene repair therapy for muscular dystrophies. However, conflicting evidence exists on whether AAV9 transduces MuSCs. To rigorously address this question, we used a muscle graft model. The grafted muscle underwent complete necrosis before regenerating from its MuSCs. We injected AA…
  • Recombinant vector vaccine evolution. [Journal Article]
    PLoS Comput Biol 2019; 15(7):e1006857Bull JJ, Nuismer SL, Antia R
  • Replicating recombinant vector vaccines consist of a fully competent viral vector backbone engineered to express an antigen from a foreign transgene. From the perspective of viral replication, the transgene is not only dispensable but may even be detrimental. Thus vaccine revertants that delete or inactivate the transgene may evolve to dominate the vaccine virus population both during the process…
  • Mutagenicity assessment of food contact material migrates with the Ames MPF assay. [Journal Article]
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019; 36(9):1419-1432Rainer B, Mayrhofer E, … Tacker M
  • A major challenge in the safety assessment of food contact materials (FCM) is the evaluation of unknown non-intentionally added substances (NIAS). Even though consumer exposure levels may be quantitatively low, these substances are considered to be of high toxicological concern if they act as DNA reactive mutagens. From a safety assessment perspective, it is therefore important to detect their pr…
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