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3,118 results
  • Effect of phenotypic switching on biofilm traits in Candida tropicalis. [Journal Article]
    Microb Pathog. 2020 Jun 17; 149:104346.Moralez AP, Perini HF, … Furlaneto MC
  • Candida tropicalis can undergo multiple forms of phenotypic switching. We have reported a switching system in C. tropicalis that is associated with changes in virulence attributes. We aimed to assess biofilm formation by distinct switch states of C. tropicalis and evaluate whether their sessile cells exhibit altered virulence traits. C. tropicalis strains included the parental phenotype (a clinic…
  • No Genotoxicity Is Detectable for Escherichia coli Strain Nissle 1917 by Standard In Vitro and In Vivo Tests. [Journal Article]
    Eur J Microbiol Immunol (Bp). 2020 Apr 07; 10(1):11-19.Dubbert S, Klinkert B, … von Bünau R
  • Probiotic Escherichia coli strain Nissle 1917 (EcN) has a long history of safe use. However, the recently discovered presence of a pks locus in its genome presumably producing colibactin has questioned its safety, as colibactin has been implicated in genotoxicity. Here, we assess the genotoxic potential of EcN. Metabolic products were tested in vitro by the Ames test, a mutagenicity assay develop…
  • The Pivotal Roles of US3 Protein in Cell-to-Cell Spread and Virion Nuclear Egress of Duck Plague Virus. [Journal Article]
    Sci Rep. 2020 Apr 28; 10(1):7181.Deng L, Wang M, … Chen X
  • The duck plague virus (DPV) US3 protein, a homolog of the herpes simplex virus-1 (HSV-1) US3 protein that is reported to be critical for viral replication, has been minimally studied. Therefore, to investigate the function of the DPV US3 protein, we used scarless Red recombination technology based on an infectious bacterial artificial chromosome (BAC) containing the DPV Chinese virulent strain (C…
  • Homeostatic Cytokines Drive Epigenetic Reprogramming of Activated T Cells into a "Naive-Memory" Phenotype. [Journal Article]
    iScience. 2020 Mar 19; 23(4):100989.Frumento G, Verma K, … Chen FE
  • Primary stimulation of T cells is believed to trigger unidirectional differentiation from naive to effector and memory subsets. Here we demonstrate that IL-7 can drive the phenotypic reversion of recently differentiated human central and effector memory CD8+ T cells into a naive-like phenotype. These "naive-revertant" cells display a phenotype similar to that of previously reported stem cell memo…
  • The caspase-like Gpi8 subunit of Candida albicans GPI transamidase is a metal-dependent endopeptidase. [Journal Article]
    Biochem Biophys Res Commun. 2020 Feb 18 [Online ahead of print]Sah SK, Shefali S, … Komath SS
  • GPI anchored proteins (GPI-APs) act at the frontiers of cells, decoding environmental cues and determining host-pathogen interactions in several lower eukaryotes. They are also essential for viability in lower eukaryotes. The GPI biosynthetic pathway begins at the ER and follows a roughly linear pathway to generate the complete precursor (CP) glycolipid. The GPI transamidase (GPIT) transfers this…
  • The Bacillus Subtilis K-State Promotes Stationary-Phase Mutagenesis via Oxidative Damage. [Journal Article]
    Genes (Basel). 2020 02 11; 11(2)Martin HA, Kidman AA, … Robleto EA
  • Bacterial cells develop mutations in the absence of cellular division through a process known as stationary-phase or stress-induced mutagenesis. This phenomenon has been studied in a few bacterial models, including Escherichia coli and Bacillus subtilis; however, the underlying mechanisms between these systems differ. For instance, RecA is not required for stationary-phase mutagenesis in B. subti…
  • Recombination-induced revertant mosaicism in ichthyosis with confetti and loricrin keratoderma. [Review]
    J Dermatol Sci. 2020 Feb; 97(2):94-100.Nomura T
  • Revertant mosaicism refers to a condition in which a pathogenic germline mutation is spontaneously corrected in somatic cells, resulting in the presence of two or more cell populations with different genotypes in an organism arising from a single fertilized egg. If the revertant cells are clonally expanded due to a survival advantage over the surrounding mutant cells, patients benefit from this s…
  • Genotoxicity assessment of triclocarban by comet and micronucleus assays and Ames test. [Journal Article]
    Environ Sci Pollut Res Int. 2020 Mar; 27(7):7430-7438.Sun D, Zhao T, … Zhang Z
  • The widespread usage and ubiquitous distribution of triclocarban (3,4,4'-trichlorocarbanilide, TCC) have raised public concerns about its health effects. At present, there is little information about the genotoxicity of TCC. In this study, we used a battery of genotoxicity testing methods including salmonella reverse mutation test (Ames test), comet assay and micronucleus assay to detect the effe…
  • Gene therapy for severe combined immunodeficiencies and beyond. [Journal Article]
    J Exp Med. 2020 Jan 06; 217(2)Fischer A, Hacein-Bey-Abina S
  • Ex vivo retrovirally mediated gene therapy has been shown within the last 20 yr to correct the T cell immunodeficiency caused by γc-deficiency (SCID X1) and adenosine deaminase (ADA) deficiency. The rationale was brought up by the observation of the revertant of SCIDX1 and ADA deficiency as a kind of natural gene therapy. Nevertheless, the first attempts of gene therapy for SCID X1 were associate…
  • An MPER antibody neutralizes HIV-1 using germline features shared among donors. [Journal Article]
    Nat Commun. 2019 11 26; 10(1):5389.Zhang L, Irimia A, … Zwick MB
  • The membrane-proximal external region (MPER) of HIV-1 envelope glycoprotein (Env) can be targeted by neutralizing antibodies of exceptional breadth. MPER antibodies usually have long, hydrophobic CDRH3s, lack activity as inferred germline precursors, are often from the minor IgG3 subclass, and some are polyreactive, such as 4E10. Here we describe an MPER broadly neutralizing antibody from the maj…
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