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5,730 results
  • BPEI-Induced Delocalization of PBP4 Potentiates β-lactams Against MRSA. [Journal Article]
    Biochemistry 2019Hill MA, Lam AK, … Rice CV
  • With its high morbidity rate and increasing resistance to treatment, methicillin-resistant Staphylococcus aureus (MRSA) is a grave concern in the medical field. In methicillin-susceptible strains, β-lactam antibiotics disable the penicillin binding proteins (PBPs) that crosslink the bacterial cell wall. However, methicillin-resistant strains have PBP2a and PBP4, which continue enzymatic activity …
  • RAPA-ConvNets: Modified Convolutional Networks for Accelerated Training on Architectures With Analog Arrays. [Journal Article]
    Front Neurosci 2019; 13:753Rasch MJ, Gokmen T, … Haensch W
  • Analog arrays are a promising emerging hardware technology with the potential to drastically speed up deep learning. Their main advantage is that they employ analog circuitry to compute matrix-vector products in constant time, irrespective of the size of the matrix. However, ConvNets map very unfavorably onto analog arrays when done in a straight-forward manner, because kernel matrices are typica…
  • Hormonal Replacement Therapy in Menopausal Women with History of Endometriosis: A Review of Literature. [Review]
    Medicina (Kaunas) 2019; 55(8)Zanello M, Borghese G, … Seracchioli R
  • Hormonal replacement therapy (HRT) is effective in treating the symptoms of menopause. Endometriosis is defined as the presence of functional endometrial tissue outside the uterine cavity with a tendency towards invasion and infiltration. Being an estrogen-dependent disease, it tends to regress after menopause. Nevertheless, it affects up to 2.2% of postmenopausal women. Conclusive data are not a…
  • The attack and defense games. [Comment]
    Behav Brain Sci 2019; 42:e140Sheremeta RM
  • The attack-and-defense game is a game in which an attacker (a group of attackers) has an incentive to revise the status quo and a defender (a group of defenders) wants to protect it. The asymmetry in objectives creates incompatible interests and results in a mixed-strategy Nash equilibrium. However, this equilibrium could be heavily impacted by behavioral considerations.
  • The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease. [Journal Article]
    Eur J Med Chem 2019; 181:111572Mesiti F, Chavarria D, … Borges F
  • The discovery and development of multitarget-directed ligands (MTDLs) is a promising strategy to find new therapeutic solutions for neurodegenerative diseases (NDs), in particular for Alzheimer's disease (AD). Currently approved drugs for the clinical management of AD are based on a single-target strategy and focus on restoring neurotransmitter homeostasis. Finding disease-modifying therapies AD …
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