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450 results
  • Melorheostosis: A Clinical, Pathologic, and Radiologic Case Series. [Journal Article]
    Am J Surg Pathol 2019Fick CN, Fratzl-Zelman N, … Bhattacharyya T
  • Melorheostosis is a rare sclerosing bone disease characterized by excessive cortical bone deposition that is frequently on the differential diagnosis for bone biopsies. Although the radiologic pattern of "dripping candle wax" is well known, the pathologic findings have been poorly defined. Here, we comprehensively describe the histology of melorheostosis in 15 patients who underwent bone biopsies…
  • Melorheostosis and Osteopoikilosis Clinical and Molecular Description of an Italian Case Series. [Journal Article]
    Calcif Tissue Int 2019; 105(2):215-221Gnoli M, Staals EL, … Sangiorgi L
  • Melorheostosis (MEL) is an uncommon, sclerosing disease, characterised by hyperostosis of long bones, resembling the flowing of candle wax. The disease is sporadic and the pathogenesis is still poorly understood. Occasionally, the same family can include individuals with MEL and Osteopoikilosis (OPK), a disease characterised by multiple round foci of increased bone density. LEMD3 gene mutations a…
  • Melorheostosis in the pediatric hand. [Journal Article]
    Clin Case Rep 2019; 7(5):1110-1111Farr S
  • It is important to consider the rare case of a melorheostosis in patients presenting with soft tissue swelling, joint contractures, and "dripping candle wax"-like hyperostoses visible on hand radiographs. Clinical sequelae such as carpal tunnel syndrome or trigger finger have to be ruled out. Symptomatic therapy is usually sufficient.
  • Melorheostosis and Osteopoikilosis: A Review of Clinical Features and Pathogenesis. [Review]
    Calcif Tissue Int 2019; 104(5):530-543Wordsworth P, Chan M
  • Melorheostosis is an exceptionally rare sclerosing hyperostosis that typically affects the appendicular skeleton in a limited segmental fashion. It occasionally occurs on a background of another benign generalised sclerosing bone condition, known as osteopoikilosis caused by germline mutations in LEMD3, encoding the inner nuclear membrane protein MAN1, which modulates TGFβ/bone morphogenetic prot…
  • Melorheostosis with an associated para-articular enhancing soft tissue mass. [Journal Article]
    Clin Imaging 2019 Jul - Aug; 56:9-12Manning P, Nguyen TB, Smitaman E
  • Melorheostosis is a rare non-hereditary sclerosing bone dysplasia which predominantly affects the appendicular skeleton. Although melorheostosis is typically recognized as an osseous lesion, associated soft-tissue components have been reported. Advanced imaging with MRI may allow for more complete evaluation of these soft tissue components; however, there is little information regarding their MRI…
  • Osteoma-like melorheostosis: a rare type of skeletal dysplasia depicted on FDG PET/CT. [Journal Article]
    Skeletal Radiol 2019; 48(8):1299-1303Abi-Ghanem AS, Asmar K, … Muwakkit S
  • Melorheostosis, also known as Leri's disease, is a rare benign form of mesodermal mixed sclerosing bone dysplasia. We report the unusual case of a 14-year-old boy with melorheostosis in the lower extremity that went undiagnosed due to concurrent Ewing sarcoma in the opposite limb, confounding the findings for metastatic disease. The diagnosis was made on FDG PET/CT when the patient presented for …
  • Melorheostosis of The Leg: A Case Report. [Case Reports]
    J Radiol Case Rep 2018; 12(11):12-17Alothman M, Alkhamees L, Al Subaie AM
  • Melorheostosis is a benign hyperostotic disease of the peripheral skeleton, rarely involving the axial skeleton. This disease is associated with ossified and non-ossified soft tissue masses surrounding the joints. We report the case of a 28-year-old male who presented to an orthopedic clinic with a chronic history of right leg pain. Radiological evaluation using X-ray, computed tomography, and ma…
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