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235,907 results
  • Citrullinated peptide epitope targets therapeutic nanoparticles to human neutrophils. [Journal Article]
    Bioconjug Chem 2019Khatri S, Hansen J, … Astakhova K
  • Multiple drugs have been proposed for reducing harsh symptoms of human rheumatic diseases. However, a targeted therapy with mild to no side-effects is still missing. In this study, we have prepared and tested a series of therapeutic nanoparticles for specific targeting of human neutrophils associated with rheumatoid arthritis. In doing this, a series of citrullinated peptide epitopes derived from…
  • JAK inhibitors for the treatment of autoimmune and inflammatory diseases. [Review]
    Autoimmun Rev 2019; :102390Jamilloux Y, El Jammal T, … Sève P
  • Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide array of cytokines. JAK inhibitors are increasingly used in the setting of inflammatory and autoimmune diseases. While the currently approved drugs are panJAK inhibitors, more …
  • Fast track algorithm: How to differentiate a "scleroderma pattern" from a "non-scleroderma pattern". [Review]
    Autoimmun Rev 2019; :102394Smith V, Vanhaecke A, … EULAR Study Group on Microcirculation in Rheumatic Diseases
  • CONCLUSIONS: For the first time, a clinical expert based fast track decision algorithm has been developed to differentiate a "non-scleroderma" from a "scleroderma pattern" on capillaroscopic images, demonstrating excellent reliability when applied by capillaroscopists with varying levels of expertise versus the principal expert and corroborated with external validation.
  • Genetics of rheumatic fever and rheumatic heart disease. [Review]
    Nat Rev Cardiol 2019Muhamed B, Parks T, Sliwa K
  • Rheumatic heart disease (RHD) is a complication of group A streptococcal infection that results from a complex interaction between the genetic make-up of the host, the infection itself and several other environmental factors, largely reflecting poverty. RHD is estimated to affect 33.4 million people and results in 10.5 million disability-adjusted life-years lost globally. The disease has long bee…
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