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244,409 results
  • Rheumatic manifestations in inflammatory bowel disease. [Journal Article]
    Minerva Gastroenterol Dietol. 2020 Jul 03 [Online ahead of print]Finucci A, Ditto MC, … Fusaro E
  • Rheumatic manifestations are the most frequent extra-intestinal manifestations (EIMs) in Inflammatory Bowel Disease (IBD) patients, and they are responsible for a relevant reduction of quality of life. IBD is associated with a variety of musculoskeletal manifestations such as arthritis and non-inflammatory pain as well as with metabolic diseases, such as osteoporosis. Different imaging techniques…
  • IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases. [Journal Article]
    Sci Rep. 2020 Jul 03; 10(1):11010.Thiagarajan D, Oparina N, … Frostegård J
  • IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular and rheumatic diseases. We here compare these antibodies in systemic rheumatic conditions and study their properties. Anti-PC and anti-MDA was measured using ELISA in patients with SLE (374), RA (354), Mixed connective tissue disease (MCTD, 77), Systemic sclerosis (SS…
  • Piper sarmentosum Roxb.: A review on its botany, traditional uses, phytochemistry, and pharmacological activities. [Review]
    J Ethnopharmacol. 2020 Jun 30 [Online ahead of print]Sun X, Chen W, … Han T
  • CONCLUSIONS: There is convincing evidence from both in vitro and in vivo studies supporting the traditional use of P. sarmentosum and it is imperative that natural bioactive compounds are examined further. More efforts should be focused on the pharmacodynamic constituents of P. sarmentosum to provide practical basis for quality control, and additional studies are needed to understand the mechanism of their action. Further studies on the comprehensive evaluation of medicinal quality and understandings of serum chemistry, multi-target network pharmacology, and molecular docking technology of P. sarmentosum are of great importance and should be considered.
  • Therapeutic approaches in the treatment of gout. [Review]
    Semin Arthritis Rheum. 2020 Jun; 50(3S):S24-S30.Pillinger MH, Mandell BF
  • Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for …
  • Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19. [Journal Article]
    Expert Rev Clin Immunol. 2020 Jul 03 [Online ahead of print]Sattui SE, Liew JW, … Sparks JA
  • Several months into the COVID-19 pandemic, safe and effective treatments against this global health disaster have yet to be identified. Clinical research trials around the world are underway testing a wide array of possible medications. In particular, the off-label use of hydroxychloroquine for COVID-19 prophylaxis and treatment has created many unprecedented challenges for the scientific communi…
  • The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease. [Review]
    Infect Chemother. 2020 Jun; 52(2):252-280.Seo YB, Moon SJ, … Lee SS
  • To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and the Korean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vacc…
  • [Non-inflammatory muscle pain]. [Journal Article]
    Dtsch Med Wochenschr. 2020 Jul; 145(13):887-894.Roicke H, Köhler W, … Krasselt M
  • Muscle pain as a common symptom in daily practice frequently occurs as a non-specific accompanying symptom in multiple internal and neurological diseases. Primarily inflammatory or autoimmune muscular diseases are causing muscle pain. However, a number of non-inflammatory causes of pain can also be considered for differential diagnosis. These are presented in this article. In principle, a distinc…
  • Mapping clinical outcomes to generic preference-based outcome measures: development and comparison of methods. [Journal Article]
    Health Technol Assess. 2020 Jun; 24(34):1-68.Hernández Alava M, Wailoo A, … Manca A
  • CONCLUSIONS: Case studies drew heavily on EuroQoL-5 Dimensions. Indirect methods could not be undertaken for several case studies because of a lack of coverage. These methods will often be unfeasible for preference-based measures with complex descriptive systems.Mapping requires appropriate methods to yield reliable results. Evidence shows that widely used methods such as linear regression are inappropriate. More flexible methods developed specifically for mapping show that close-fitting results can be achieved. Approaches based on mixture models are appropriate for all preference-based measures. Some features are universally required (such as the minimum number of components) but others must be assessed on a case-by-case basis (such as the location and number of probability mass points).
  • Understanding the Brain and Exploring the Effects of Clinical Fatigue: From a Patient's Perspective. [Journal Article]
    Adv Exp Med Biol. 2020; 1262:149-181.Zurowski J, Poyade M, Bennett L
  • Rheumatic and musculoskeletal diseases are a group of devastating autoimmune disorders that all share a common debilitating symptom fatigue. Fatigue is not widely understood and is often underrepresented in treatment regimes. Fatigue is the least successfully managed symptom of these conditions; however, it can often be the one of the greatest impairments.Augmented reality (AR) enhances a person'…
  • The multifaceted functional role of DNA methylation in immune-mediated rheumatic diseases. [Review]
    Clin Rheumatol. 2020 Jul 02 [Online ahead of print]Vecellio M, Wu H, … Selmi C
  • Genomic predisposition cannot explain the onset of complex diseases, as well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodelling and non-coding RNA, are considered to be the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory dis…
  • Tuberculosis and targeted synthetic or biologic DMARDs, beyond tumor necrosis factor inhibitors. [Review]
    Ther Adv Musculoskelet Dis. 2020; 12:1759720X20930116.Evangelatos G, Koulouri V, … Fragoulis GE
  • Patients with autoimmune rheumatic diseases (ARD) have an increased risk for tuberculosis (TB). The use of tumor necrosis factor inhibitors (TNFi) and glucocorticoids in these patients has been associated with an increased prevalence of latent TB reactivation. Over the last few years, several biologic disease-modifying anti-rheumatic drugs (bDMARDs), other than TNFi (e.g. rituximab, abatacept, to…
  • Fibromyalgia 2016 criteria and assessments: comprehensive validation in a Norwegian population. [Journal Article]
    Scand J Pain. 2020 Jun 30 [Online ahead of print]Fors EA, Wensaas KA, … Helvik AS
  • Background and aims The ACR1990 criteria of fibromyalgia (FM) have been criticized due to poor reliability of tender points counting (TPC), inconsistent definitions of the widespread pain, and by not considering other symptoms than pain in the FM phenotype. Therefore, several newer self-report measures for FM criteria have emerged. The aim of this study was to translate the fibromyalgia survey qu…
  • Oncorheumatology: relationship between malignancies and musculoskeletal diseases [Journal Article]
    Orv Hetil. 2020 07; 161(28):1151-1165.Szekanecz Z, Gomez I, … Szekanecz É
  • Oncorheumatology is the meeting point of tumour formation and rheumatic diseases. Multiple interactions exist between these two medical specialties. One major field is the topic of malignancies associated with rheumatic diseases, while the other topic covers the development of musculoskeletal disease in cancer patients. In the first group, secondary malignancies associated with rheumatic diseases…
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