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10,588 results
  • Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression. [Journal Article]
    Prog Neuropsychopharmacol Biol Psychiatry 2019; :109776Machado DG, de Lara MVS, … Porciúncula LO
  • Longitudinal and some experimental studies have showed the potential of caffeine to counteract some depressive behaviors and synaptic dysfunctions. In this study, we investigated the potential of caffeine in preventing behavioral outcomes, neurodegeneration and synaptic proteins alterations in a mice model of agitated depression by bilateral olfactory bulbectomy (OB). For this purpose, bulbectomi…
  • Human Olfaction without Apparent Olfactory Bulbs. [Journal Article]
    Neuron 2019Weiss T, Soroka T, … Sobel N
  • The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection…
  • Neural Dynamics of Associative Learning during Human Sleep. [Journal Article]
    Cereb Cortex 2019Canales-Johnson A, Merlo E, … Arzi A
  • Recent evidence indicates that humans can learn entirely new information during sleep. To elucidate the neural dynamics underlying sleep-learning, we investigated brain activity during auditory-olfactory discriminatory associative learning in human sleep. We found that learning-related delta and sigma neural changes are involved in early acquisition stages, when new associations are being formed.…
  • Regional Distribution of Glycogen in the Mouse Brain Visualized by Immunohistochemistry. [Journal Article]
    Adv Neurobiol 2019; 23:147-168Oe Y, Akther S, Hirase H
  • Considering that the brain constantly consumes a substantial amount of energy, the nature of its energy reserve is an important issue. Although the brain is rich in lipid content encompassing membranes, myelin sheath, and astrocytic lipid droplets, it is devoid of adipose tissue which serves as an energy reserve. Notably, glycogen represents the major energy store in the brain. While glycogen has…
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